| http://purl.uniprot.org/citations/26412237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26412237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26412237 | http://www.w3.org/2000/01/rdf-schema#comment | "Adherens junctions (AJs) are membrane-anchored structures composed of E-cadherin and associated proteins, including catenins and actin. The unique plasticity of AJs mediates both the rigidity and flexibility of cell-cell contacts essential for embryonic morphogenesis and adult tissue remodeling. We identified the SUMO protease ULP-2 as a regulator of AJ assembly and show that dysregulated ULP-2 activity impairs epidermal morphogenesis in Caenorhabditis elegans embryos. The conserved cytoplasmic tail of HMR-1/E-cadherin is sumoylated and is a target of ULP-2 desumoylation activity. Coupled sumoylation and desumoylation of HMR-1 are required for its recruitment to the subapical membrane during AJ assembly and the formation of the linkages between AJs and the apical actin cytoskeleton. Sumoylation weakens HMR-1 binding to HMP-2/β-catenin. Our study provides a mechanistic link between the dynamic nature of the SUMO machinery and AJ plasticity and highlight sumoylation as a molecular switch that modulates the binding of E-cadherin to the actin cytoskeleton."xsd:string |
| http://purl.uniprot.org/citations/26412237 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2015.08.019"xsd:string |
| http://purl.uniprot.org/citations/26412237 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2015.08.019"xsd:string |
| http://purl.uniprot.org/citations/26412237 | http://purl.uniprot.org/core/author | "Broday L."xsd:string |
| http://purl.uniprot.org/citations/26412237 | http://purl.uniprot.org/core/author | "Broday L."xsd:string |
| http://purl.uniprot.org/citations/26412237 | http://purl.uniprot.org/core/author | "Tsur A."xsd:string |
| http://purl.uniprot.org/citations/26412237 | http://purl.uniprot.org/core/author | "Tsur A."xsd:string |
| http://purl.uniprot.org/citations/26412237 | http://purl.uniprot.org/core/author | "Bening Abu-Shach U."xsd:string |
| http://purl.uniprot.org/citations/26412237 | http://purl.uniprot.org/core/author | "Bening Abu-Shach U."xsd:string |
| http://purl.uniprot.org/citations/26412237 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26412237 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26412237 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/26412237 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/26412237 | http://purl.uniprot.org/core/pages | "63-77"xsd:string |
| http://purl.uniprot.org/citations/26412237 | http://purl.uniprot.org/core/pages | "63-77"xsd:string |
| http://purl.uniprot.org/citations/26412237 | http://purl.uniprot.org/core/title | "ULP-2 SUMO Protease Regulates E-Cadherin Recruitment to Adherens Junctions."xsd:string |
| http://purl.uniprot.org/citations/26412237 | http://purl.uniprot.org/core/title | "ULP-2 SUMO Protease Regulates E-Cadherin Recruitment to Adherens Junctions."xsd:string |
| http://purl.uniprot.org/citations/26412237 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/26412237 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/26412237 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26412237 |
| http://purl.uniprot.org/citations/26412237 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26412237 |
| http://purl.uniprot.org/citations/26412237 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26412237 |
| http://purl.uniprot.org/citations/26412237 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26412237 |