| http://purl.uniprot.org/citations/26412335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26412335 | http://www.w3.org/2000/01/rdf-schema#comment | "Translation initiation in the P site occasionally occurs at atypical (non-AUG) start codons, including those forming a mismatch in the third (wobble) position. During elongation, however, a pyrimidine-pyrimidine wobble mismatch may trigger a translation quality-control mechanism, whereby the P-site mismatch is thought to perturb the downstream A-site codon or the decoding center, thereby reducing translation fidelity and inducing termination of aberrant translation. We report a crystal structure of the 70S initiation complex containing an AUC codon in the ribosomal P site. Remarkably, the ribosome stabilizes the mismatched codon-anticodon helix, arranging a normally disruptive cytosine-cytosine pair into a Watson-Crick-like conformation. Translation-competent conformations of the tRNA, mRNA, and decoding center suggest that a P-site wobble-position mismatch in the 70S initiation complex does not pre-arrange the mRNA or decoding center to favor subsequent miscoding events."xsd:string |
| http://purl.uniprot.org/citations/26412335 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2015.08.011"xsd:string |
| http://purl.uniprot.org/citations/26412335 | http://purl.uniprot.org/core/author | "Korostelev A.A."xsd:string |
| http://purl.uniprot.org/citations/26412335 | http://purl.uniprot.org/core/author | "Svidritskiy E."xsd:string |
| http://purl.uniprot.org/citations/26412335 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26412335 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/26412335 | http://purl.uniprot.org/core/pages | "2155-2161"xsd:string |
| http://purl.uniprot.org/citations/26412335 | http://purl.uniprot.org/core/title | "Ribosome Structure Reveals Preservation of Active Sites in the Presence of a P-Site Wobble Mismatch."xsd:string |
| http://purl.uniprot.org/citations/26412335 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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