| http://purl.uniprot.org/citations/26416272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26416272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26416272 | http://www.w3.org/2000/01/rdf-schema#comment | "The peptide-loading complex plays a pivotal role in Ag processing and is thus central to the efficient immune recognition of virally and malignantly transformed cells. The underlying mechanism by which MHC class I (MHC I) molecules sample immunodominant peptide epitopes, however, remains poorly understood. In this article, we delineate the interaction between tapasin (Tsn) and MHC I molecules. We followed the process of peptide editing in real time after ultra-fast photoconversion to pseudoempty MHC I molecules. Tsn discriminates between MHC I loaded with optimal and MHC I bound to suboptimal cargo. This differential interaction is key to understanding the kinetics of epitope proofreading. To elucidate the underlying mechanism at the atomic level, we modeled the Tsn/MHC I complex using all-atom molecular dynamics simulations. We present a catalytic working cycle, in which Tsn binds to MHC I with suboptimal cargo and thereby adjusts the energy landscape in favor of MHC I complexes with immunodominant epitopes."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1501515"xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1501515"xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Thomas C."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Thomas C."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Tampe R."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Tampe R."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Tumulka F."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Tumulka F."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Springer S."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Springer S."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Schaefer L.V."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Schaefer L.V."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Fisette O."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Fisette O."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Fleischmann G."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Fleischmann G."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Schneeweiss C."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Schneeweiss C."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Wieneke R."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/author | "Wieneke R."xsd:string |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26416272 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |