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http://purl.uniprot.org/citations/26416603http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Background

Invasion of host cells by Trypanosoma cruzi extracellular amastigotes is host actin polymerization-dependent. However, the role of proteins related to actin dynamics during invasion by amastigotes remains to be investigated. Here we describe the role of Annexin A2 and ARF-6 during extracellular amastigote-mammalian cell interactions.

Findings

Our results showed ARF-6 accumulation in the amastigote-containing parasitophorous vacuole containing amastigote forms; demonstrated ARF-6 and Annexin A2 critical impact over parasite cell invasion and revealed the effect of Annexin A2 expression on intracellular parasite multiplication.

Conclusion

ARF-6 and Annexin A2 are involved in invasion of mammalian cells by T. cruzi amastigotes."xsd:string
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http://purl.uniprot.org/citations/26416603http://purl.uniprot.org/core/author"Cruz L."xsd:string
http://purl.uniprot.org/citations/26416603http://purl.uniprot.org/core/author"Mortara R.A."xsd:string
http://purl.uniprot.org/citations/26416603http://purl.uniprot.org/core/author"Da Silva C.V."xsd:string
http://purl.uniprot.org/citations/26416603http://purl.uniprot.org/core/author"Teixeira T.L."xsd:string
http://purl.uniprot.org/citations/26416603http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/26416603http://purl.uniprot.org/core/name"Parasit Vectors"xsd:string
http://purl.uniprot.org/citations/26416603http://purl.uniprot.org/core/pages"493"xsd:string
http://purl.uniprot.org/citations/26416603http://purl.uniprot.org/core/title"Revealing Annexin A2 and ARF-6 enrollment during Trypanosoma cruzi extracellular amastigote-host cell interaction."xsd:string
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