| http://purl.uniprot.org/citations/26417084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26417084 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphatidylserine (PtdSer) exposure on the surface of activated platelets requires the action of a phospholipid scramblase(s), and serves as a scaffold for the assembly of the tenase and prothrombinase complexes involved in blood coagulation. Here, we found that the activation of mouse platelets with thrombin/collagen or Ca(2+) ionophore at 20 °C induces PtdSer exposure without compromising plasma membrane integrity. Among five transmembrane protein 16 (TMEM16) members that support Ca(2+)-dependent phospholipid scrambling, TMEM16F was the only one that showed high expression in mouse platelets. Platelets from platelet-specific TMEM16F-deficient mice exhibited defects in activation-induced PtdSer exposure and microparticle shedding, although α-granule and dense granule release remained intact. The rate of tissue factor-induced thrombin generation by TMEM16F-deficient platelets was severely reduced, whereas thrombin-induced clot retraction was unaffected. The imaging of laser-induced thrombus formation in whole animals showed that PtdSer exposure on aggregated platelets was TMEM16F-dependent in vivo. The phenotypes of the platelet-specific TMEM16F-null mice resemble those of patients with Scott syndrome, a mild bleeding disorder, indicating that these mice may provide a useful model for human Scott syndrome."xsd:string |
| http://purl.uniprot.org/citations/26417084 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1516594112"xsd:string |
| http://purl.uniprot.org/citations/26417084 | http://purl.uniprot.org/core/author | "Fujii T."xsd:string |
| http://purl.uniprot.org/citations/26417084 | http://purl.uniprot.org/core/author | "Nishimura S."xsd:string |
| http://purl.uniprot.org/citations/26417084 | http://purl.uniprot.org/core/author | "Nagata S."xsd:string |
| http://purl.uniprot.org/citations/26417084 | http://purl.uniprot.org/core/author | "Eto K."xsd:string |
| http://purl.uniprot.org/citations/26417084 | http://purl.uniprot.org/core/author | "Sakata A."xsd:string |
| http://purl.uniprot.org/citations/26417084 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26417084 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/26417084 | http://purl.uniprot.org/core/pages | "12800-12805"xsd:string |
| http://purl.uniprot.org/citations/26417084 | http://purl.uniprot.org/core/title | "TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets."xsd:string |
| http://purl.uniprot.org/citations/26417084 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/26417084 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26417084 |
| http://purl.uniprot.org/citations/26417084 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26417084 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPX3-mappedCitation-26417084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26417084 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPY8-mappedCitation-26417084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26417084 |
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| http://purl.uniprot.org/uniprot/#_Q6P9J9-mappedCitation-26417084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26417084 |
| http://purl.uniprot.org/uniprot/A0A2I3BRD2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26417084 |
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| http://purl.uniprot.org/uniprot/A0A2I3BPX3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26417084 |