| http://purl.uniprot.org/citations/26418898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26418898 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously showed that S-adenosylmethionine-mediated hypermethylation of the PTEN promoter was important for the growth of tamoxifen-resistant MCF-7 (TAMR-MCF-7) cancer cells. Here, we found that the basal expression level of methionine adenosyltransferase 2A (MAT2A), a critical enzyme for the biosynthesis of S-adenosylmethionine, was up-regulated in TAMR-MCF-7 cells compared with control MCF-7 cells. Moreover, the basal expression level of MAT2A in T47D cells, a TAM-resistant estrogen receptor-positive cell line was higher compared to MCF-7 cells. Immunohistochemistry confirmed that MAT2A expression in TAM-resistant human breast cancer tissues was higher than that in TAM-responsive cases. The promoter region of human MAT2A contains binding sites for nuclear factor-κB, activator protein-1 (AP-1), and NF-E2-related factor 2 (Nrf2), and the activities of these three transcription factors were enhanced in TAMR-MCF-7 cells. Both the protein expression and transcriptional activity of MAT2A in TAMR-MCF-7 cells were potently suppressed by NF-κB inhibition but not by c-Jun/AP-1 or Nrf2 knock-down. Interestingly, the expression levels of microRNA (miR)-146a and -146b were diminished in TAMR-MCF-7 cells, and miR-146b transduction decreased NF-κB-mediated MAT2A expression. miR-146b restored PTEN expression via the suppression of PTEN promoter methylation in TAMR-MCF-7 cells. Additionally, miR-146b overexpression inhibited cell proliferation and reversed chemoresistance to 4-hydroxytamoxifen in TAMR-MCF-7 cells."xsd:string |
| http://purl.uniprot.org/citations/26418898 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.5298"xsd:string |
| http://purl.uniprot.org/citations/26418898 | http://purl.uniprot.org/core/author | "Kim S.K."xsd:string |
| http://purl.uniprot.org/citations/26418898 | http://purl.uniprot.org/core/author | "Lee K.Y."xsd:string |
| http://purl.uniprot.org/citations/26418898 | http://purl.uniprot.org/core/author | "Yang J.W."xsd:string |
| http://purl.uniprot.org/citations/26418898 | http://purl.uniprot.org/core/author | "Yoon J.H."xsd:string |
| http://purl.uniprot.org/citations/26418898 | http://purl.uniprot.org/core/author | "Kim Y.M."xsd:string |
| http://purl.uniprot.org/citations/26418898 | http://purl.uniprot.org/core/author | "Lim S.C."xsd:string |
| http://purl.uniprot.org/citations/26418898 | http://purl.uniprot.org/core/author | "Im J.H."xsd:string |
| http://purl.uniprot.org/citations/26418898 | http://purl.uniprot.org/core/author | "Choi M.C."xsd:string |
| http://purl.uniprot.org/citations/26418898 | http://purl.uniprot.org/core/author | "Kang K.W."xsd:string |
| http://purl.uniprot.org/citations/26418898 | http://purl.uniprot.org/core/author | "Phuong N.T."xsd:string |
| http://purl.uniprot.org/citations/26418898 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26418898 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/26418898 | http://purl.uniprot.org/core/pages | "13902-13916"xsd:string |
| http://purl.uniprot.org/citations/26418898 | http://purl.uniprot.org/core/title | "Induction of methionine adenosyltransferase 2A in tamoxifen-resistant breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/26418898 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/26418898 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26418898 |
| http://purl.uniprot.org/citations/26418898 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26418898 |
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| http://purl.uniprot.org/uniprot/#_B4DFQ8-mappedCitation-26418898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26418898 |
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| http://purl.uniprot.org/uniprot/#_B4DEX8-mappedCitation-26418898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26418898 |