| http://purl.uniprot.org/citations/26419928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26419928 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucocorticoids (GCs) affect the proliferation of growth plate chondrocytes. In this study, we investigated the role of the GC-inducible promyelocytic leukemia zinc finger (PLZF) gene in chondrocyte differentiation by using the chondrogenic cell line ATDC5. PLZF overexpression suppressed cell cycle progression (p < 0.01) and promoted differentiation into hypertrophic chondrocytes by inducing mRNA expression of alkaline phosphatase (p < 0.01), and the cyclin-dependent kinase (CDK) inhibitor p21 (p < 0.01). In contrast, PLZF knockdown impaired differentiation into hypertrophic chondrocytes and promoted cell cycle progression (p < 0.01). Treatment with the GC analogue dexamethasone (10(-6) M) suppressed cell cycle progression in ATDC5 cells. PLZF shRNA attenuated dexamethasone-induced cell cycle arrest (p < 0.01) by downregulating the mRNA expression of the CDK inhibitors p21 and p57 (p < 0.01). These results clearly indicated that PLZF promoted differentiation into hypertrophic chondrocytes and mediated dexamethasone-induced cell cycle arrest by regulating CDK inhibitors."xsd:string |
| http://purl.uniprot.org/citations/26419928 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2015.09.026"xsd:string |
| http://purl.uniprot.org/citations/26419928 | http://purl.uniprot.org/core/author | "Ohashi A."xsd:string |
| http://purl.uniprot.org/citations/26419928 | http://purl.uniprot.org/core/author | "Takahashi T."xsd:string |
| http://purl.uniprot.org/citations/26419928 | http://purl.uniprot.org/core/author | "Naito M."xsd:string |
| http://purl.uniprot.org/citations/26419928 | http://purl.uniprot.org/core/author | "Tsukune N."xsd:string |
| http://purl.uniprot.org/citations/26419928 | http://purl.uniprot.org/core/author | "Vongsa S."xsd:string |
| http://purl.uniprot.org/citations/26419928 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26419928 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/26419928 | http://purl.uniprot.org/core/pages | "114-123"xsd:string |
| http://purl.uniprot.org/citations/26419928 | http://purl.uniprot.org/core/title | "Promyelocytic leukemia zinc finger mediates glucocorticoid-induced cell cycle arrest in the chondroprogenitor cell line ATDC5."xsd:string |
| http://purl.uniprot.org/citations/26419928 | http://purl.uniprot.org/core/volume | "417"xsd:string |
| http://purl.uniprot.org/citations/26419928 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26419928 |
| http://purl.uniprot.org/citations/26419928 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26419928 |
| http://purl.uniprot.org/uniprot/#_A3KMN0-mappedCitation-26419928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26419928 |
| http://purl.uniprot.org/uniprot/#_Q3UQ17-mappedCitation-26419928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26419928 |
| http://purl.uniprot.org/uniprot/A3KMN0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26419928 |
| http://purl.uniprot.org/uniprot/Q3UQ17 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26419928 |