| http://purl.uniprot.org/citations/26423150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26423150 | http://www.w3.org/2000/01/rdf-schema#comment | "N-myristoylation refers to the attachment of myristic acid to the N-terminal glycine of proteins and substantially affects their intracellular targeting and functions. The thymus represents an organ with a prominent N-myristoylation activity. To elucidate the role of protein N-myristoylation for thymocyte development, we generated mice with a T cell lineage-specific deficiency in N-myristoyl transferase (Nmt)1 and 2. Depletion of Nmt activity in T cells led to a defective transmission of TCR signals, a developmental blockage of thymocytes at the transition from double-negative 3 to 4 stages, and a reduction of all the following stages. We could demonstrate that Lck and myristoylated alanine-rich C kinase substrate, two main myristoylated kinases in T cells, were mislocalized in the absence of Nmt activity. N-myristoylation was also indispensable for early and distal TCR signaling events such as CD3ζ, Zap70, and Erk activation and for release of cytokines such as IFN-γ and IL-2. As a consequence, the initiation and propagation of the TCR signaling cascade was severely impaired. Furthermore, we showed that the absence of myristoylation had an immunosuppressive effect on T cells in vivo after treatment with CpG and stimulation of the TCR with the staphylococcal enterotoxin B superantigen. Therefore, protein myristoylation is indispensable in T cell development and activation and its inhibition might offer a novel strategy to achieve immunosuppression."xsd:string |
| http://purl.uniprot.org/citations/26423150 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1500622"xsd:string |
| http://purl.uniprot.org/citations/26423150 | http://purl.uniprot.org/core/author | "Lehmann W.D."xsd:string |
| http://purl.uniprot.org/citations/26423150 | http://purl.uniprot.org/core/author | "Grone H.J."xsd:string |
| http://purl.uniprot.org/citations/26423150 | http://purl.uniprot.org/core/author | "Porubsky S."xsd:string |
| http://purl.uniprot.org/citations/26423150 | http://purl.uniprot.org/core/author | "Boehm M.E."xsd:string |
| http://purl.uniprot.org/citations/26423150 | http://purl.uniprot.org/core/author | "Bonrouhi M."xsd:string |
| http://purl.uniprot.org/citations/26423150 | http://purl.uniprot.org/core/author | "Kaden S."xsd:string |
| http://purl.uniprot.org/citations/26423150 | http://purl.uniprot.org/core/author | "Federico G."xsd:string |
| http://purl.uniprot.org/citations/26423150 | http://purl.uniprot.org/core/author | "Popovic Z.V."xsd:string |
| http://purl.uniprot.org/citations/26423150 | http://purl.uniprot.org/core/author | "Rampoldi F."xsd:string |
| http://purl.uniprot.org/citations/26423150 | http://purl.uniprot.org/core/author | "Brunk F."xsd:string |
| http://purl.uniprot.org/citations/26423150 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26423150 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/26423150 | http://purl.uniprot.org/core/pages | "4228-4243"xsd:string |
| http://purl.uniprot.org/citations/26423150 | http://purl.uniprot.org/core/title | "Immunosuppression and Aberrant T Cell Development in the Absence of N-Myristoylation."xsd:string |
| http://purl.uniprot.org/citations/26423150 | http://purl.uniprot.org/core/volume | "195"xsd:string |
| http://purl.uniprot.org/citations/26423150 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26423150 |
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| http://purl.uniprot.org/uniprot/#_O70311-mappedCitation-26423150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26423150 |