| http://purl.uniprot.org/citations/26427875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26427875 | http://www.w3.org/2000/01/rdf-schema#comment | "Damage-associated molecular patterns (DAMPs), so-called "danger signals," play important roles in host defense and pathophysiology in mammals and insects. In Drosophila, the Toll pathway confers damage responses during bacterial infection and improper cell-fate control. However, the intrinsic ligands and signaling mechanisms that potentiate innate immune responses remain unknown. Here, we demonstrate that a Drosophila larva-derived tissue extract strongly elicits Toll pathway activation via the Toll receptor. Using this extract, we performed ex vivo genome-wide RNAi screening in Drosophila cultured cells, and identified several signaling factors that are required for host defense and antimicrobial-peptide expression in Drosophila adults. These results suggest that our larva-derived tissue extract contains active ingredients that mediate Toll pathway activation, and the screening data will shed light on the mechanisms of damage-related Toll pathway signaling in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/26427875 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2015.09.138"xsd:string |
| http://purl.uniprot.org/citations/26427875 | http://purl.uniprot.org/core/author | "Watanabe R."xsd:string |
| http://purl.uniprot.org/citations/26427875 | http://purl.uniprot.org/core/author | "Nagata S."xsd:string |
| http://purl.uniprot.org/citations/26427875 | http://purl.uniprot.org/core/author | "Kurata S."xsd:string |
| http://purl.uniprot.org/citations/26427875 | http://purl.uniprot.org/core/author | "Kanoh H."xsd:string |
| http://purl.uniprot.org/citations/26427875 | http://purl.uniprot.org/core/author | "Kuraishi T."xsd:string |
| http://purl.uniprot.org/citations/26427875 | http://purl.uniprot.org/core/author | "Tong L.L."xsd:string |
| http://purl.uniprot.org/citations/26427875 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26427875 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/26427875 | http://purl.uniprot.org/core/pages | "400-406"xsd:string |
| http://purl.uniprot.org/citations/26427875 | http://purl.uniprot.org/core/title | "Ex vivo genome-wide RNAi screening of the Drosophila Toll signaling pathway elicited by a larva-derived tissue extract."xsd:string |
| http://purl.uniprot.org/citations/26427875 | http://purl.uniprot.org/core/volume | "467"xsd:string |
| http://purl.uniprot.org/citations/26427875 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26427875 |
| http://purl.uniprot.org/citations/26427875 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26427875 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DHG9-mappedCitation-26427875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26427875 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHY4-mappedCitation-26427875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26427875 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6R9-mappedCitation-26427875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26427875 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7Z3-mappedCitation-26427875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26427875 |
| http://purl.uniprot.org/uniprot/#_A4V3J9-mappedCitation-26427875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26427875 |
| http://purl.uniprot.org/uniprot/#_A4V2B8-mappedCitation-26427875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26427875 |
| http://purl.uniprot.org/uniprot/#_A8JRF7-mappedCitation-26427875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26427875 |
| http://purl.uniprot.org/uniprot/#_B7Z0R6-mappedCitation-26427875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26427875 |
| http://purl.uniprot.org/uniprot/#_P49762-mappedCitation-26427875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26427875 |