| http://purl.uniprot.org/citations/26433463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26433463 | http://www.w3.org/2000/01/rdf-schema#comment | "Foxp3(+) regulatory T cells (Tregs) are often highly enriched within the tumor-infiltrating T cell pool. Using a well-characterised model of carcinogen-induced fibrosarcomas we show that the enriched tumor-infiltrating Treg population comprises largely of CXCR3(+) T-bet(+) 'TH1-like' Tregs which are thymus-derived Helios(+) cells. Whilst IL-2 maintains homeostatic ratios of Tregs in lymphoid organs, we found that the perturbation in Treg frequencies in tumors is IL-2 independent. Moreover, we show that the TH1 phenotype of tumor-infiltrating Tregs is dispensable for their ability to influence tumor progression. We did however find that unlike Tconvs, the majority of intra-tumoral Tregs express the activation markers CD69, CD25, ICOS, CD103 and CTLA4 and are significantly more proliferative than Tconvs. Moreover, we have found that CD69(+) Tregs are more suppressive than their CD69-counterparts. Collectively, these data indicate superior activation of Tregs in the tumor microenvironment, promoting their suppressive ability and selective proliferation at this site."xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.5584"xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/author | "Price D.A."xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/author | "Bloom A."xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/author | "Ladell K."xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/author | "Jones E."xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/author | "Smart K."xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/author | "Gallimore A.M."xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/author | "Godkin A.J."xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/author | "Hindley J.P."xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/author | "O'Connor R.A."xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/author | "Anderton S.M."xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/author | "Bridgeman H."xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/author | "Turner D.G."xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/author | "McPherson R.C."xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/author | "Colbeck E.J."xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/pages | "24649-24659"xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/title | "Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors."xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26433463 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26433463 |
| http://purl.uniprot.org/citations/26433463 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26433463 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC35-mappedCitation-26433463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26433463 |