| http://purl.uniprot.org/citations/26435691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26435691 | http://www.w3.org/2000/01/rdf-schema#comment | "Unbalanced tumor necrosis factor (TNF)-α production is associated with pathogenesis of a variety of human diseases. However, the molecular pathways maintaining TNF-α homeostasis remain elusive. Here, we report that NF-κB/p65-DICER-miRs axis negatively regulates TNF-α production. We demonstrated that NF-κB bound to DICER promoter and transcriptionally regulated DICER expression. In addition, the NF-κB/DICER signaling suppresses TNF-α expression by generating mature forms of miR-125b and miR-130a which negatively regulate TNF-α mRNA. Furthermore, we showed that the hepatocyte-specific depletion of Dicer in mice resulted in TNF-α overproduction and sensitized the mice to endotoxin, which could be corrected by administration of miR-125b mimics. These data suggest that NF-κB/p65-DICER-miRs axis involved in maintaining of TNF-α homeostasis, and injection of miR-125b as a potential therapeutic method for septic shock."xsd:string |
| http://purl.uniprot.org/citations/26435691 | http://purl.org/dc/terms/identifier | "doi:10.7150/ijbs.12611"xsd:string |
| http://purl.uniprot.org/citations/26435691 | http://purl.uniprot.org/core/author | "Guan Y."xsd:string |
| http://purl.uniprot.org/citations/26435691 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/26435691 | http://purl.uniprot.org/core/author | "Yao H."xsd:string |
| http://purl.uniprot.org/citations/26435691 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/26435691 | http://purl.uniprot.org/core/author | "Cao L."xsd:string |
| http://purl.uniprot.org/citations/26435691 | http://purl.uniprot.org/core/author | "Sun K."xsd:string |
| http://purl.uniprot.org/citations/26435691 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26435691 | http://purl.uniprot.org/core/name | "Int J Biol Sci"xsd:string |
| http://purl.uniprot.org/citations/26435691 | http://purl.uniprot.org/core/pages | "1257-1268"xsd:string |
| http://purl.uniprot.org/citations/26435691 | http://purl.uniprot.org/core/title | "NF-kappaB-DICER-miRs Axis Regulates TNF-alpha Expression in Responses to Endotoxin Stress."xsd:string |
| http://purl.uniprot.org/citations/26435691 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/26435691 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26435691 |
| http://purl.uniprot.org/citations/26435691 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26435691 |
| http://purl.uniprot.org/uniprot/Q9UPY3#attribution-C247C7CA24E363D7EC3C66E140427E14 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26435691 |
| http://purl.uniprot.org/uniprot/Q9UPY3#attribution-D4954591F7D2E4604D02EE70C1EE0111 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26435691 |