| http://purl.uniprot.org/citations/26438726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26438726 | http://www.w3.org/2000/01/rdf-schema#comment | "Adult neural stem/precursor cells (NSPCs) of the subventricular zone (SVZ) are an endogenous source for neuronal replacement in CNS disease. However, adult neurogenesis is compromised after brain injury in favor of a glial cell fate, which is mainly attributed to changes in the NSPC environment. Yet, it is unknown how this unfavorable extracellular environment translates into a transcriptional program altering NSPC differentiation. Here, we show that genetic depletion of the transcriptional regulator Id3 decreased the number of astrocytes generated from SVZ-derived adult NSPCs in the cortical lesion area after traumatic brain injury. Cortical brain injury resulted in rapid BMP-2 and Id3 up-regulation in the SVZ stem cell niche. Id3(-/-) adult NSPCs failed to differentiate into BMP-2-induced astrocytes, while NSPCs deficient for the Id3-controlled transcription factor E47 readily differentiated into astrocytes in the absence of BMP-2. Mechanistically, E47 repressed the expression of several astrocyte-specific genes in adult NSPCs. These results identify Id3 as the BMP-2-induced transcriptional regulator, promoting adult NSPC differentiation into astrocytes upon CNS injury and reveal a molecular link between environmental changes and NSPC differentiation in the CNS after injury."xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.201591118"xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/author | "Dengjel J."xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/author | "Pfeifer D."xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/author | "Kirsch M."xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/author | "Schachtrup C."xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/author | "Schachtrup K."xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/author | "Hils M."xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/author | "Dumit V.I."xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/author | "Plappert L."xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/author | "Rauch K.S."xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/author | "Mammadzada K."xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/author | "Bohrer C."xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/author | "Pfurr S."xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/author | "Pous L."xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/author | "Schildge S."xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/pages | "2804-2819"xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/title | "The balance of Id3 and E47 determines neural stem/precursor cell differentiation into astrocytes."xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/26438726 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26438726 |
| http://purl.uniprot.org/citations/26438726 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26438726 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J011-mappedCitation-26438726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26438726 |