| http://purl.uniprot.org/citations/26439008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26439008 | http://www.w3.org/2000/01/rdf-schema#comment | "Adenosine triphosphate (ATP), the chemical energy currency of biology, is synthesized in eukaryotic cells primarily by the mitochondrial ATP synthase. ATP synthases operate by a rotary catalytic mechanism where proton translocation through the membrane-inserted FO region is coupled to ATP synthesis in the catalytic F1 region via rotation of a central rotor subcomplex. We report here single particle electron cryomicroscopy (cryo-EM) analysis of the bovine mitochondrial ATP synthase. Combining cryo-EM data with bioinformatic analysis allowed us to determine the fold of the a subunit, suggesting a proton translocation path through the FO region that involves both the a and b subunits. 3D classification of images revealed seven distinct states of the enzyme that show different modes of bending and twisting in the intact ATP synthase. Rotational fluctuations of the c8-ring within the FO region support a Brownian ratchet mechanism for proton-translocation-driven rotation in ATP synthases."xsd:string |
| http://purl.uniprot.org/citations/26439008 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.10180"xsd:string |
| http://purl.uniprot.org/citations/26439008 | http://purl.uniprot.org/core/author | "Grigorieff N."xsd:string |
| http://purl.uniprot.org/citations/26439008 | http://purl.uniprot.org/core/author | "Montgomery M.G."xsd:string |
| http://purl.uniprot.org/citations/26439008 | http://purl.uniprot.org/core/author | "Walker J.E."xsd:string |
| http://purl.uniprot.org/citations/26439008 | http://purl.uniprot.org/core/author | "Rubinstein J.L."xsd:string |
| http://purl.uniprot.org/citations/26439008 | http://purl.uniprot.org/core/author | "Zhou A."xsd:string |
| http://purl.uniprot.org/citations/26439008 | http://purl.uniprot.org/core/author | "Rohou A."xsd:string |
| http://purl.uniprot.org/citations/26439008 | http://purl.uniprot.org/core/author | "Bason J.V."xsd:string |
| http://purl.uniprot.org/citations/26439008 | http://purl.uniprot.org/core/author | "Schep D.G."xsd:string |
| http://purl.uniprot.org/citations/26439008 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26439008 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/26439008 | http://purl.uniprot.org/core/pages | "e10180"xsd:string |
| http://purl.uniprot.org/citations/26439008 | http://purl.uniprot.org/core/title | "Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM."xsd:string |
| http://purl.uniprot.org/citations/26439008 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/26439008 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26439008 |
| http://purl.uniprot.org/citations/26439008 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26439008 |
| http://purl.uniprot.org/uniprot/#_P00829-mappedCitation-26439008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26439008 |
| http://purl.uniprot.org/uniprot/#_P00847-mappedCitation-26439008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26439008 |
| http://purl.uniprot.org/uniprot/#_P13619-mappedCitation-26439008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26439008 |
| http://purl.uniprot.org/uniprot/#_P13620-mappedCitation-26439008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26439008 |
| http://purl.uniprot.org/uniprot/#_P13621-mappedCitation-26439008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26439008 |
| http://purl.uniprot.org/uniprot/#_P02721-mappedCitation-26439008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26439008 |
| http://purl.uniprot.org/uniprot/#_P05630-mappedCitation-26439008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26439008 |