| http://purl.uniprot.org/citations/26443850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26443850 | http://www.w3.org/2000/01/rdf-schema#comment | "Accurate completion of replication relies on the ability of cells to activate error-free recombination-mediated DNA damage bypass at sites of perturbed replication. However, as anti-recombinase activities are also recruited to replication forks, how recombination-mediated damage bypass is enabled at replication stress sites remained puzzling. Here we uncovered that the conserved SUMO-like domain-containing Saccharomyces cerevisiae protein Esc2 facilitates recombination-mediated DNA damage tolerance by allowing optimal recruitment of the Rad51 recombinase specifically at sites of perturbed replication. Mechanistically, Esc2 binds stalled replication forks and counteracts the anti-recombinase Srs2 helicase via a two-faceted mechanism involving chromatin recruitment and turnover of Srs2. Importantly, point mutations in the SUMO-like domains of Esc2 that reduce its interaction with Srs2 cause suboptimal levels of Rad51 recruitment at damaged replication forks. In conclusion, our results reveal how recombination-mediated DNA damage tolerance is locally enabled at sites of replication stress and globally prevented at undamaged replicating chromosomes."xsd:string |
| http://purl.uniprot.org/citations/26443850 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.265629.115"xsd:string |
| http://purl.uniprot.org/citations/26443850 | http://purl.uniprot.org/core/author | "Krejci L."xsd:string |
| http://purl.uniprot.org/citations/26443850 | http://purl.uniprot.org/core/author | "Sollier J."xsd:string |
| http://purl.uniprot.org/citations/26443850 | http://purl.uniprot.org/core/author | "Branzei D."xsd:string |
| http://purl.uniprot.org/citations/26443850 | http://purl.uniprot.org/core/author | "Szakal B."xsd:string |
| http://purl.uniprot.org/citations/26443850 | http://purl.uniprot.org/core/author | "Sebesta M."xsd:string |
| http://purl.uniprot.org/citations/26443850 | http://purl.uniprot.org/core/author | "Sisakova A."xsd:string |
| http://purl.uniprot.org/citations/26443850 | http://purl.uniprot.org/core/author | "Menolfi D."xsd:string |
| http://purl.uniprot.org/citations/26443850 | http://purl.uniprot.org/core/author | "Urulangodi M."xsd:string |
| http://purl.uniprot.org/citations/26443850 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26443850 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/26443850 | http://purl.uniprot.org/core/pages | "2067-2080"xsd:string |
| http://purl.uniprot.org/citations/26443850 | http://purl.uniprot.org/core/title | "Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication."xsd:string |
| http://purl.uniprot.org/citations/26443850 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/26443850 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26443850 |
| http://purl.uniprot.org/citations/26443850 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26443850 |
| http://purl.uniprot.org/uniprot/#_A0A8H8UNQ9-mappedCitation-26443850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26443850 |
| http://purl.uniprot.org/uniprot/#_P40072-mappedCitation-26443850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26443850 |
| http://purl.uniprot.org/uniprot/#_Q06340-mappedCitation-26443850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26443850 |
| http://purl.uniprot.org/uniprot/#_Q12050-mappedCitation-26443850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26443850 |
| http://purl.uniprot.org/uniprot/#_P12954-mappedCitation-26443850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26443850 |
| http://purl.uniprot.org/uniprot/#_P25454-mappedCitation-26443850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26443850 |
| http://purl.uniprot.org/uniprot/#_P32828-mappedCitation-26443850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26443850 |