| http://purl.uniprot.org/citations/26446563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26446563 | http://www.w3.org/2000/01/rdf-schema#comment | "Kinins are important vasoactive peptides, but the role of the B1 receptor subtype in the vascular control is poorly understood. This study analyzed the nitric oxide (NO) release, L-arginine (L-Arg) uptake and the expression of the cationic amino acid transporter (CAT) -1 in endothelial cells obtained from B1 receptor knockout (B1-/-) and wild type (WT) mice. NO production was assessed through a fluorescent dye in living cells stimulated with acetylcholine. L-Arg uptake was determined indirectly in the culture medium by HPLC, in the presence or absence of the CAT-1 blocker N-ethylmaleimide (NEM). CAT-1 mRNA levels and protein expression were determined by qPCR and western blot, respectively. NO release was significantly reduced in B1-/-when compared to WT cells. This result was accompanied by a decreased rate in the L-Arg uptake by B1-/-cells. Incubation with NEM impaired the L-Arg uptake in WT, but had no effect in B1-/- cells. Protein expression and mRNA levels for CAT-1 were reduced in B1-/-in comparison to WT cells. These findings suggest an important role of the endothelial B1 receptor in the vascular control by interfering with CAT-1 expression, L-Arg uptake and NO release."xsd:string |
| http://purl.uniprot.org/citations/26446563 | http://purl.org/dc/terms/identifier | "doi:10.2174/0929866522666151008151422"xsd:string |
| http://purl.uniprot.org/citations/26446563 | http://purl.uniprot.org/core/author | "Fernandes L."xsd:string |
| http://purl.uniprot.org/citations/26446563 | http://purl.uniprot.org/core/author | "Landgraf R.G."xsd:string |
| http://purl.uniprot.org/citations/26446563 | http://purl.uniprot.org/core/author | "Loiola R.A."xsd:string |
| http://purl.uniprot.org/citations/26446563 | http://purl.uniprot.org/core/author | "Assuncao N.A."xsd:string |
| http://purl.uniprot.org/citations/26446563 | http://purl.uniprot.org/core/author | "Correa-Noronh S.A."xsd:string |
| http://purl.uniprot.org/citations/26446563 | http://purl.uniprot.org/core/author | "Gil N.L."xsd:string |
| http://purl.uniprot.org/citations/26446563 | http://purl.uniprot.org/core/author | "Torres T.C."xsd:string |
| http://purl.uniprot.org/citations/26446563 | http://purl.uniprot.org/core/author | "Tudela R.C."xsd:string |
| http://purl.uniprot.org/citations/26446563 | http://purl.uniprot.org/core/author | "de Noronha S.M."xsd:string |
| http://purl.uniprot.org/citations/26446563 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26446563 | http://purl.uniprot.org/core/name | "Protein Pept Lett"xsd:string |
| http://purl.uniprot.org/citations/26446563 | http://purl.uniprot.org/core/pages | "1111-1116"xsd:string |
| http://purl.uniprot.org/citations/26446563 | http://purl.uniprot.org/core/title | "L-Arginine Transport and Nitric Oxide Production in Kinin Receptor B1-/- Endothelial Cells."xsd:string |
| http://purl.uniprot.org/citations/26446563 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/26446563 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26446563 |
| http://purl.uniprot.org/citations/26446563 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26446563 |
| http://purl.uniprot.org/uniprot/#_Q0VBD7-mappedCitation-26446563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26446563 |
| http://purl.uniprot.org/uniprot/#_Q61125-mappedCitation-26446563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26446563 |
| http://purl.uniprot.org/uniprot/Q0VBD7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26446563 |
| http://purl.uniprot.org/uniprot/Q61125 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26446563 |