| http://purl.uniprot.org/citations/26449471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26449471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26449471 | http://www.w3.org/2000/01/rdf-schema#comment | "Leucine is a proteogenic amino acid that also regulates many aspects of mammalian physiology, in large part by activating the mTOR complex 1 (mTORC1) protein kinase, a master growth controller. Amino acids signal to mTORC1 through the Rag guanosine triphosphatases (GTPases). Several factors regulate the Rags, including GATOR1, aGTPase-activating protein; GATOR2, a positive regulator of unknown function; and Sestrin2, a GATOR2-interacting protein that inhibits mTORC1 signaling. We find that leucine, but not arginine, disrupts the Sestrin2-GATOR2 interaction by binding to Sestrin2 with a dissociation constant of 20 micromolar, which is the leucine concentration that half-maximally activates mTORC1. The leucine-binding capacity of Sestrin2 is required for leucine to activate mTORC1 in cells. These results indicate that Sestrin2 is a leucine sensor for the mTORC1 pathway."xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aab2674"xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aab2674"xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/author | "Sabatini D.M."xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/author | "Sabatini D.M."xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/author | "Shen K."xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/author | "Shen K."xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/author | "Cantor J.R."xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/author | "Cantor J.R."xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/author | "Chantranupong L."xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/author | "Chantranupong L."xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/author | "Saxton R.A."xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/author | "Saxton R.A."xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/author | "Scaria S.M."xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/author | "Scaria S.M."xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/author | "Wolfson R.L."xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/author | "Wolfson R.L."xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/pages | "43-48"xsd:string |
| http://purl.uniprot.org/citations/26449471 | http://purl.uniprot.org/core/pages | "43-48"xsd:string |