| http://purl.uniprot.org/citations/26455318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26455318 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite abundant data supporting c-Src as a metastasis-promoting oncogene, activating mutations of c-Src are rare. This suggests that trans-interacting proteins may have a critical role in regulating c-Src activation. Here, we first report the discovery of Src homology 3 (SH3) domain-binding glutamic acid-rich-like protein (SH3BGRL), a novel c-Src activator in mice. Ectopic expression of murine SH3BGRL (mSH3BGRL) strongly promoted both tumor cell invasion and lung metastasis. Molecularly, mSH3BGRL specifically bound the inactive form of c-Src phosphorylated at Tyr527, promoting Tyr416 phosphorylation of c-Src and subsequent FAK-mediated activation of ERK and AKT signaling pathways. Targeting endogenous c-Src alone was sufficient to abolish mSH3BGRL-induced cancer metastasis in vivo. Unexpectedly, human SH3BGRL (hSH3BGRL) in turn suppressed tumorigenesis and metastasis in nature. We attempted site-specific reversion of hSH3BGRL amino-acid sequence to mSH3BGRL and found V108A substitution sufficient to restore SH3BGRL function as a c-Src activator and metastasis promoter. Notably, the somatic mutation R76C of hSH3BGRL can similarly act as hSH3BGRL-V108A and mSH3BGRL in tumorigenesis and metastasis. Our results uncover an evolutionarily controversial role of SH3BGRL in driving tumor metastasis through c-Src activation, and suggests that hSH3BGRL mutation status could be relevant to cancer diagnosis and therapy."xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2015.391"xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://purl.uniprot.org/core/author | "Guo K."xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://purl.uniprot.org/core/author | "Liu B."xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://purl.uniprot.org/core/author | "Tan B.C."xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://purl.uniprot.org/core/author | "Zeng Q."xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://purl.uniprot.org/core/author | "Shi H."xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://purl.uniprot.org/core/author | "Tang J.P."xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://purl.uniprot.org/core/author | "Loo J.M."xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://purl.uniprot.org/core/author | "Thura M."xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://purl.uniprot.org/core/author | "Al-Aidaroos A.Q."xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26455318 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://purl.uniprot.org/core/pages | "3303-3313"xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://purl.uniprot.org/core/title | "Dual-faced SH3BGRL: oncogenic in mice, tumor suppressive in humans."xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/26455318 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26455318 |
| http://purl.uniprot.org/citations/26455318 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26455318 |
| http://purl.uniprot.org/uniprot/#_B0AZV6-mappedCitation-26455318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26455318 |
| http://purl.uniprot.org/uniprot/#_P34152-mappedCitation-26455318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26455318 |
| http://purl.uniprot.org/uniprot/#_O75368-mappedCitation-26455318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26455318 |