| http://purl.uniprot.org/citations/26456112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26456112 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms by which intrinsically disordered proteins engage in rapid and highly selective binding is a subject of considerable interest and represents a central paradigm to nuclear pore complex (NPC) function, where nuclear transport receptors (NTRs) move through the NPC by binding disordered phenylalanine-glycine-rich nucleoporins (FG-Nups). Combining single-molecule fluorescence, molecular simulations, and nuclear magnetic resonance, we show that a rapidly fluctuating FG-Nup populates an ensemble of conformations that are prone to bind NTRs with near diffusion-limited on rates, as shown by stopped-flow kinetic measurements. This is achieved using multiple, minimalistic, low-affinity binding motifs that are in rapid exchange when engaging with the NTR, allowing the FG-Nup to maintain an unexpectedly high plasticity in its bound state. We propose that these exceptional physical characteristics enable a rapid and specific transport mechanism in the physiological context, a notion supported by single molecule in-cell assays on intact NPCs."xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2015.09.047"xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://purl.uniprot.org/core/author | "Blackledge M."xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://purl.uniprot.org/core/author | "Koehler C."xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://purl.uniprot.org/core/author | "Tyagi S."xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://purl.uniprot.org/core/author | "Jensen M.R."xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://purl.uniprot.org/core/author | "Milles S."xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://purl.uniprot.org/core/author | "Mercadante D."xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://purl.uniprot.org/core/author | "Clarke J."xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://purl.uniprot.org/core/author | "Lemke E.A."xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://purl.uniprot.org/core/author | "Banterle N."xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://purl.uniprot.org/core/author | "Grater F."xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://purl.uniprot.org/core/author | "Shammas S.L."xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://purl.uniprot.org/core/author | "Aramburu I.V."xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26456112 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://purl.uniprot.org/core/pages | "734-745"xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://purl.uniprot.org/core/title | "Plasticity of an ultrafast interaction between nucleoporins and nuclear transport receptors."xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://purl.uniprot.org/core/volume | "163"xsd:string |
| http://purl.uniprot.org/citations/26456112 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26456112 |
| http://purl.uniprot.org/citations/26456112 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26456112 |
| http://purl.uniprot.org/uniprot/#_Q02199-mappedCitation-26456112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26456112 |
| http://purl.uniprot.org/uniprot/#_P30822-mappedCitation-26456112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26456112 |
| http://purl.uniprot.org/uniprot/#_P33331-mappedCitation-26456112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26456112 |