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http://purl.uniprot.org/citations/26457306http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26457306http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the correlation of CTRP9 with coronary atherosclerosis.

Methods

Coronary angiography confirmed CAD in 241 patients (62 received CABG) and non-CAD in 121 (55 received valve replacement).

Results

Serum levels of LDL-C, CRP, TNF-α, IL-6, and leptin in CAD patients were significantly higher than those in non-CAD patients (P < 0.05), but APN and CTRP9 were lower (P < 0.05). Serum levels of CTRP9 and APN were negatively related to BMI, HOMA-IR, TNF-α, IL-6, and leptin but positively to HDL-C (P < 0.05) in CAD patients. After adjustment of APN, CTRP9 was still related to the above parameters. Serum CTRP9 was a protective factor of CAD (P < 0.05). When compared with non-CAD patients, leptin mRNA expression increased dramatically, while CTRP9 mRNA expression reduced markedly in epicardial adipose tissue of CAD patients (P < 0.05). The leptin expression and macrophage count in CAD group were significantly higher than in non-CAD group, but CAD patients had a markedly lower CTRP9 expression (P < 0.05).

Conclusions

Circulating and coronary CTRP9 plays an important role in the inflammation and coronary atherosclerosis of CAD patients. Serum CTRP9 is an independent protective factor of CAD."xsd:string
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http://purl.uniprot.org/citations/26457306http://purl.uniprot.org/core/author"Wang J."xsd:string
http://purl.uniprot.org/citations/26457306http://purl.uniprot.org/core/author"Wang L.J."xsd:string
http://purl.uniprot.org/citations/26457306http://purl.uniprot.org/core/author"Li D.M."xsd:string
http://purl.uniprot.org/citations/26457306http://purl.uniprot.org/core/author"Zhang Q.G."xsd:string
http://purl.uniprot.org/citations/26457306http://purl.uniprot.org/core/author"Hang T."xsd:string
http://purl.uniprot.org/citations/26457306http://purl.uniprot.org/core/author"Peng Y.P."xsd:string
http://purl.uniprot.org/citations/26457306http://purl.uniprot.org/core/author"Gong J.B."xsd:string
http://purl.uniprot.org/citations/26457306http://purl.uniprot.org/core/author"Cheng X.M."xsd:string
http://purl.uniprot.org/citations/26457306http://purl.uniprot.org/core/date"2015"xsd:gYear
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http://purl.uniprot.org/citations/26457306http://purl.uniprot.org/core/title"Associations of C1q/TNF-Related Protein-9 Levels in Serum and Epicardial Adipose Tissue with Coronary Atherosclerosis in Humans."xsd:string
http://purl.uniprot.org/citations/26457306http://purl.uniprot.org/core/volume"2015"xsd:string
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