| http://purl.uniprot.org/citations/26461455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26461455 | http://www.w3.org/2000/01/rdf-schema#comment | "CD70-mediated stimulation of CD27 is an important cofactor of CD4(+) T-cell licensed dendritic cells (DCs). However, it is unclear how CD70-mediated stimulation of T cells is integrated with signals that emanate from signal 3 pathways, such as type-1 interferon (IFN-1) and IL-12. We find that while stimulation of CD27 in isolation drives weak Eomesodermin(hi) T-bet(lo) CD8(+) T-cell responses to OVA immunization, profound synergistic expansion is achieved by cotargeting TLR. This cooperativity can substantially boost antiviral CD8(+) T-cell responses during acute infection. Concomitant stimulation of TLR significantly increases per cell IFN-γ production and the proportion of the population with characteristics of short-lived effector cells, yet also promotes the ability to form long-lived memory. Notably, while IFN-1 contributes to the expression of CD70 on DCs, the synergy between CD27 and TLR stimulation is dependent upon IFN-1's effect directly on CD8(+) T cells, and is associated with the increased expression of T-bet in T cells. Surprisingly, we find that IL-12 fails to synergize with CD27 stimulation to promote CD8(+) T-cell expansion, despite its capacity to drive effector CD8(+) T-cell differentiation. Together, these data identify complex interactions between signal 3 and costimulatory pathways, and identify opportunities to influence the differentiation of CD8(+) T-cell responses."xsd:string |
| http://purl.uniprot.org/citations/26461455 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201445291"xsd:string |
| http://purl.uniprot.org/citations/26461455 | http://purl.uniprot.org/core/author | "Dong H."xsd:string |
| http://purl.uniprot.org/citations/26461455 | http://purl.uniprot.org/core/author | "Yagita H."xsd:string |
| http://purl.uniprot.org/citations/26461455 | http://purl.uniprot.org/core/author | "Glennie M.J."xsd:string |
| http://purl.uniprot.org/citations/26461455 | http://purl.uniprot.org/core/author | "Bullock T.N."xsd:string |
| http://purl.uniprot.org/citations/26461455 | http://purl.uniprot.org/core/author | "Franklin N.A."xsd:string |
| http://purl.uniprot.org/citations/26461455 | http://purl.uniprot.org/core/author | "Ritchea S.B."xsd:string |
| http://purl.uniprot.org/citations/26461455 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26461455 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/26461455 | http://purl.uniprot.org/core/pages | "3289-3301"xsd:string |
| http://purl.uniprot.org/citations/26461455 | http://purl.uniprot.org/core/title | "CD70 and IFN-1 selectively induce eomesodermin or T-bet and synergize to promote CD8+ T-cell responses."xsd:string |
| http://purl.uniprot.org/citations/26461455 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/26461455 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26461455 |
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