| http://purl.uniprot.org/citations/26464284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26464284 | http://www.w3.org/2000/01/rdf-schema#comment | "In addition to antigen processing, immunoproteasomes were recently shown to exert functions influencing cytokine production by monocytes and T cells, T-helper cell differentiation, and T-cell survival. Moreover, selective inhibition of the immunoproteasome subunit LMP7 ameliorated symptoms of autoimmune diseases including CD4(+) T-cell mediated EAE. In this study, we show that LMP7 also plays a crucial role in the pathogenesis of lymphocytic choriomeningitis virus (LCMV)-induced meningitis mediated by CTLs. Mice lacking functional LMP7 display delayed and reduced clinical signs of disease accompanied by a strongly decreased inflammatory infiltration into the brain. Interestingly, we found that selective inhibition and genetic deficiency of LMP7 affect the pathogenesis of LCMV-induced meningitis in a distinct manner. Our findings support the important role of LMP7 in inflammatory disorders and suggest immunoproteasome inhibition as a novel strategy against inflammation-induced neuropathology in the CNS."xsd:string |
| http://purl.uniprot.org/citations/26464284 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201545578"xsd:string |
| http://purl.uniprot.org/citations/26464284 | http://purl.uniprot.org/core/author | "Engelhardt B."xsd:string |
| http://purl.uniprot.org/citations/26464284 | http://purl.uniprot.org/core/author | "Basler M."xsd:string |
| http://purl.uniprot.org/citations/26464284 | http://purl.uniprot.org/core/author | "Groettrup M."xsd:string |
| http://purl.uniprot.org/citations/26464284 | http://purl.uniprot.org/core/author | "Mundt S."xsd:string |
| http://purl.uniprot.org/citations/26464284 | http://purl.uniprot.org/core/author | "Kirk C.J."xsd:string |
| http://purl.uniprot.org/citations/26464284 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26464284 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/26464284 | http://purl.uniprot.org/core/pages | "104-113"xsd:string |
| http://purl.uniprot.org/citations/26464284 | http://purl.uniprot.org/core/title | "Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis."xsd:string |
| http://purl.uniprot.org/citations/26464284 | http://purl.uniprot.org/core/volume | "46"xsd:string |
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