| http://purl.uniprot.org/citations/26471740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26471740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26471740 | http://www.w3.org/2000/01/rdf-schema#comment | "Assembly and maturation of synapses at the Drosophila neuromuscular junction (NMJ) depend on trans-synaptic neurexin/neuroligin signalling, which is promoted by the scaffolding protein Syd-1 binding to neurexin. Here we report that the scaffold protein spinophilin binds to the C-terminal portion of neurexin and is needed to limit neurexin/neuroligin signalling by acting antagonistic to Syd-1. Loss of presynaptic spinophilin results in the formation of excess, but atypically small active zones. Neuroligin-1/neurexin-1/Syd-1 levels are increased at spinophilin mutant NMJs, and removal of single copies of the neurexin-1, Syd-1 or neuroligin-1 genes suppresses the spinophilin-active zone phenotype. Evoked transmission is strongly reduced at spinophilin terminals, owing to a severely reduced release probability at individual active zones. We conclude that presynaptic spinophilin fine-tunes neurexin/neuroligin signalling to control active zone number and functionality, thereby optimizing them for action potential-induced exocytosis."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms9362"xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms9362"xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Holt M."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Holt M."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Wahl M.C."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Wahl M.C."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Sigrist S.J."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Sigrist S.J."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Loll B."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Loll B."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Schmoranzer J."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Schmoranzer J."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Hell S.W."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Hell S.W."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Rey U."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Rey U."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Scheiffele P."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Scheiffele P."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Hollmann C."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Hollmann C."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Ramesh N."xsd:string |
| http://purl.uniprot.org/citations/26471740 | http://purl.uniprot.org/core/author | "Ramesh N."xsd:string |