| http://purl.uniprot.org/citations/26473355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26473355 | http://www.w3.org/2000/01/rdf-schema#comment | "The FOXP3 gene encodes for a protein (Foxp3) involved in the development and functional activity of regulatory T cells (CD4+/CD25+/Foxp3+), which exert regulatory and suppressive roles over the immune system. After allogeneic stem cell transplantation, regulatory T cells are known to mitigate graft versus host disease while probably maintaining a graft versus leukemia effect. Short alleles (≤(GT)15) for the (GT)n polymorphism in the promoter/enhancer of FOXP3 are associated with a higher expression of FOXP3, and hypothetically with an increase of regulatory T cell activity. This polymorphism has been related to the development of auto- or alloimmune conditions including type 1 diabetes or graft rejection in renal transplant recipients. However, its impact in the allo-transplant setting has not been analyzed. In the present study, which includes 252 myeloablative HLA-identical allo-transplants, multivariate analysis revealed a lower incidence of grade III-IV acute graft versus host disease (GVHD) in patients transplanted from donors harboring short alleles (OR = 0.26, CI 0.08-0.82, p = 0.021); without affecting chronic GVHD or graft versus leukemia effect, since cumulative incidence of relapse, event free survival and overall survival rates are similar in both groups of patients."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0140454"xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Gonzalez M."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Kwon M."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Martinez C."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Solano C."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Pion M."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Brunet S."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Gallardo D."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Serrano D."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Martin-Antonio B."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Gayoso J."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Jimenez-Velasco A."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Urbano-Ispizua A."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Noriega V."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Guillem V."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Espigado I."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Nieto J.B."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Brunet S.'"xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Gallardo D.'"xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Sampol A."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Sanchez-Hernandez N."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Diez-Martin J.L."xsd:string |
| http://purl.uniprot.org/citations/26473355 | http://purl.uniprot.org/core/author | "Gonzalez M.'"xsd:string |