| http://purl.uniprot.org/citations/26478435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26478435 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) play crucial roles in the development and progression of human cancers, including gastric cancer (GC). The discovery of miRNAs may provide a new and powerful tool for studying the mechanism, diagnosis, and treatment of GC. In this study, we aimed to investigate the role and mechanism of miR-128b in the development and progression of GC. Quantitative real-time PCR (qRT-PCR) was used to measure the expression level of miR-128b in GC tissues and cell lines. We found that miR-128b was significantly down-regulated in GC tissues and cell lines. In addition, over-expression of miR-128b inhibited GC cell proliferation, migration and invasion of GC cells in vitro. Gain-of-function in vitro experiments further showed that the miR-128b mimic significantly promoted GC cell apoptosis. Subsequent dual-luciferase reporter assay identified one of the proto-oncogene A2bR as direct target of miR-128b. Therefore, our results indicate that miR-128b is a proto-oncogene miRNA that can suppresses GC proliferation and migration through down-regulation of the oncogene gene A2bR. Taken together, our results indicate that miR-128b could serve as a potential diagnostic biomarker and therapeutic option for human GC in the near future."xsd:string |
| http://purl.uniprot.org/citations/26478435 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2015.10.062"xsd:string |
| http://purl.uniprot.org/citations/26478435 | http://purl.uniprot.org/core/author | "He S."xsd:string |
| http://purl.uniprot.org/citations/26478435 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/26478435 | http://purl.uniprot.org/core/author | "Liu G."xsd:string |
| http://purl.uniprot.org/citations/26478435 | http://purl.uniprot.org/core/author | "Song B."xsd:string |
| http://purl.uniprot.org/citations/26478435 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/26478435 | http://purl.uniprot.org/core/author | "Zong W."xsd:string |
| http://purl.uniprot.org/citations/26478435 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26478435 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/26478435 | http://purl.uniprot.org/core/pages | "798-804"xsd:string |
| http://purl.uniprot.org/citations/26478435 | http://purl.uniprot.org/core/title | "MicroRNA-128b suppresses tumor growth and promotes apoptosis by targeting A2bR in gastric cancer."xsd:string |
| http://purl.uniprot.org/citations/26478435 | http://purl.uniprot.org/core/volume | "467"xsd:string |
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