| http://purl.uniprot.org/citations/26480814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26480814 | http://www.w3.org/2000/01/rdf-schema#comment | "C-terminal binding proteins (CtBPs) are transcriptional co-repressors which cooperate with a variety of transcription factors to repress gene expression. Caenorhabditis elegans CTBP-1 expression has been observed in the nervous system and hypodermis. In C. elegans, CTBP-1 regulates several processes including Acute Functional Tolerance to ethanol and functions in the nervous system to modulate both lifespan and expression of a lipase gene called lips-7. Incorrect structure and/or function of the nervous system can lead to behavioral changes. Here, we demonstrate reduced exploration behavior in ctbp-1 mutants. Our examination of a subset of neurons involved in regulating locomotion revealed that the axonal morphology of dorsal SMD (SMDD) neurons is altered in ctbp-1 mutants at the fourth larval (L4) stage. Expressing CTBP-1 under the control of the endogenous ctbp-1 promoter rescued both the exploration behavior phenotype and defective SMDD axon structure in ctbp-1 mutants at the L4 stage. Interestingly, the pre-synaptic marker RAB-3 was found to localize to the mispositioned portion of SMDD axons in a ctbp-1 mutant. Further analysis of SMDD axonal morphology at days 1, 3 and 5 of adulthood revealed that the number of ctbp-1 mutants showing an SMDD axonal morphology defect increases in early adulthood and the observed defect appears to be qualitatively more severe. CTBP-1 is prominently expressed in the nervous system with weak expression detected in the hypodermis. Surprisingly, solely expressing CTBP-1a in the nervous system or hypodermis did not restore correct SMDD axonal structure in a ctbp-1 mutant. Our results demonstrate a role for CTBP-1 in exploration behavior and the regulation of SMDD axonal morphology in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/26480814 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuroscience.2015.10.026"xsd:string |
| http://purl.uniprot.org/citations/26480814 | http://purl.uniprot.org/core/author | "Nicholas H.R."xsd:string |
| http://purl.uniprot.org/citations/26480814 | http://purl.uniprot.org/core/author | "Reid A."xsd:string |
| http://purl.uniprot.org/citations/26480814 | http://purl.uniprot.org/core/author | "Llamosas E."xsd:string |
| http://purl.uniprot.org/citations/26480814 | http://purl.uniprot.org/core/author | "Yucel D."xsd:string |
| http://purl.uniprot.org/citations/26480814 | http://purl.uniprot.org/core/author | "Sherry T.J."xsd:string |
| http://purl.uniprot.org/citations/26480814 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26480814 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/26480814 | http://purl.uniprot.org/core/pages | "216-230"xsd:string |
| http://purl.uniprot.org/citations/26480814 | http://purl.uniprot.org/core/title | "The C-terminal binding protein (CTBP-1) regulates dorsal SMD axonal morphology in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/26480814 | http://purl.uniprot.org/core/volume | "311"xsd:string |
| http://purl.uniprot.org/citations/26480814 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26480814 |
| http://purl.uniprot.org/citations/26480814 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26480814 |
| http://purl.uniprot.org/uniprot/#_Q20595-mappedCitation-26480814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26480814 |
| http://purl.uniprot.org/uniprot/Q20595 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26480814 |