| http://purl.uniprot.org/citations/26482727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26482727 | http://www.w3.org/2000/01/rdf-schema#comment | "Orofacial clefts, the most prevalent of developmental anomalies, occur with a frequency of 1 in 700 live births. Maternal cigarette smoking during pregnancy represents a risk factor for having a child with a cleft lip and/or cleft palate. Using primary cultures of first branchial arch-derived cells (1-BA cells), which contribute to the formation of the lip and palate, the present study addressed the hypothesis that components of cigarette smoke alter global DNA methylation, and/or expression of DNA methyltransferases (Dnmts) and various methyl CpG-binding proteins. Primary cultures of 1-BA cells, exposed to 80μg/mL cigarette smoke extract (CSE) for 24h, exhibited a >13% decline in global DNA methylation and triggered proteasomal-mediated degradation of Dnmts (DNMT-1 and -3a), methyl CpG binding protein 2 (MeCP2) and methyl-CpG binding domain protein 3 (MBD-3). Pretreatment of 1-BA cells with the proteasomal inhibitor MG-132 completely reversed such degradation. Collectively, these data allow the suggestion of a potential epigenetic mechanism underlying maternal cigarette smoke exposure-induced orofacial clefting."xsd:string |
| http://purl.uniprot.org/citations/26482727 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.reprotox.2015.10.009"xsd:string |
| http://purl.uniprot.org/citations/26482727 | http://purl.uniprot.org/core/author | "Greene R.M."xsd:string |
| http://purl.uniprot.org/citations/26482727 | http://purl.uniprot.org/core/author | "Pisano M.M."xsd:string |
| http://purl.uniprot.org/citations/26482727 | http://purl.uniprot.org/core/author | "Mukhopadhyay P."xsd:string |
| http://purl.uniprot.org/citations/26482727 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26482727 | http://purl.uniprot.org/core/name | "Reprod Toxicol"xsd:string |
| http://purl.uniprot.org/citations/26482727 | http://purl.uniprot.org/core/pages | "140-148"xsd:string |
| http://purl.uniprot.org/citations/26482727 | http://purl.uniprot.org/core/title | "Cigarette smoke induces proteasomal-mediated degradation of DNA methyltransferases and methyl CpG-/CpG domain-binding proteins in embryonic orofacial cells."xsd:string |
| http://purl.uniprot.org/citations/26482727 | http://purl.uniprot.org/core/volume | "58"xsd:string |
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