| http://purl.uniprot.org/citations/26483398 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26483398 | http://www.w3.org/2000/01/rdf-schema#comment | "The MHC class I chain-related molecule A (MICA) is a highly polymorphic ligand for the activating natural killer (NK)-cell receptor NKG2D. A single nucleotide polymorphism causes a valine to methionine exchange at position 129. Presence of a MICA-129Met allele in patients (n = 452) undergoing hematopoietic stem cell transplantation (HSCT) increased the chance of overall survival (hazard ratio [HR] = 0.77, P = 0.0445) and reduced the risk to die due to acute graft-versus-host disease (aGVHD) (odds ratio [OR] = 0.57, P = 0.0400) although homozygous carriers had an increased risk to experience this complication (OR = 1.92, P = 0.0371). Overall survival of MICA-129Val/Val genotype carriers was improved when treated with anti-thymocyte globulin (HR = 0.54, P = 0.0166). Functionally, the MICA-129Met isoform was characterized by stronger NKG2D signaling, triggering more NK-cell cytotoxicity and interferon-γ release, and faster co-stimulation of CD8(+) T cells. The MICA-129Met variant also induced a faster and stronger down-regulation of NKG2D on NK and CD8(+) T cells than the MICA-129Val isoform. The reduced cell surface expression of NKG2D in response to engagement by MICA-129Met variants appeared to reduce the severity of aGVHD."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.org/dc/terms/identifier | "doi:10.15252/emmm.201505246"xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/author | "Walter L."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/author | "Engelke M."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/author | "Monecke S."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/author | "Walther N."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/author | "Bickeboller H."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/author | "Stahl-Hennig C."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/author | "Kube D."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/author | "Wulf G."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/author | "von Bonin F."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/author | "Dressel R."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/author | "Elsner L."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/author | "Balavarca Y."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/author | "Malzahn D."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/author | "Kilisch M."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/author | "Isernhagen A."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/author | "Viktorova E."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/author | "Wermuth J.M."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/name | "EMBO Mol Med"xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/pages | "1480-1502"xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/title | "The MICA-129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation."xsd:string |
| http://purl.uniprot.org/citations/26483398 | http://purl.uniprot.org/core/volume | "7"xsd:string |