| http://purl.uniprot.org/citations/26485346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26485346 | http://www.w3.org/2000/01/rdf-schema#comment | "Melanoma differentiation-associated protein 5 (MDA5) and retinoic acid-inducible gene 1 (RIG-1) as the pattern recognition receptors play important roles in viral mRNA recognition. Chronic HBV-infected (CHB) patients are unable to properly respond to hepatitis B virus (HBV). Therefore, the aim of the present study was to evaluate the mRNA levels of MDA5 and RIG-1 in the peripheral blood immune cells of CHB patients in comparison to healthy controls. In this cross-sectional study, the mRNA levels of MDA5 and RIG-1 were examined in 60 CHB patients and 60 healthy controls using the real-time polymerase chain reaction (PCR) technique. Our results showed that mRNA levels of MDA5 and RIG-1 were significantly decreased and increased, respectively, in CHB patients when compared to healthy controls. Our results also revealed that mRNA levels of MDA5 and RIG-1 were not altered among CHB patients with various states of e-antigen of hepatitis B and HBV-DNA viral loads. According to the results presented here, it may be concluded that downregulation of MDA5 may be a responsible mechanism from several reasons, which leads to HBV persistence in CHB patients."xsd:string |
| http://purl.uniprot.org/citations/26485346 | http://purl.org/dc/terms/identifier | "doi:10.1089/vim.2015.0056"xsd:string |
| http://purl.uniprot.org/citations/26485346 | http://purl.uniprot.org/core/author | "Daneshvar H."xsd:string |
| http://purl.uniprot.org/citations/26485346 | http://purl.uniprot.org/core/author | "Ebrahim M."xsd:string |
| http://purl.uniprot.org/citations/26485346 | http://purl.uniprot.org/core/author | "Afrooz M.R."xsd:string |
| http://purl.uniprot.org/citations/26485346 | http://purl.uniprot.org/core/author | "Arababadi M.K."xsd:string |
| http://purl.uniprot.org/citations/26485346 | http://purl.uniprot.org/core/author | "Mirzaei V."xsd:string |
| http://purl.uniprot.org/citations/26485346 | http://purl.uniprot.org/core/author | "Shabani Z."xsd:string |
| http://purl.uniprot.org/citations/26485346 | http://purl.uniprot.org/core/author | "Bidaki R."xsd:string |
| http://purl.uniprot.org/citations/26485346 | http://purl.uniprot.org/core/author | "Karimi-Googheri M."xsd:string |
| http://purl.uniprot.org/citations/26485346 | http://purl.uniprot.org/core/author | "Khaleghinia M."xsd:string |
| http://purl.uniprot.org/citations/26485346 | http://purl.uniprot.org/core/author | "Yousefpoor Y."xsd:string |
| http://purl.uniprot.org/citations/26485346 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26485346 | http://purl.uniprot.org/core/name | "Viral Immunol"xsd:string |
| http://purl.uniprot.org/citations/26485346 | http://purl.uniprot.org/core/pages | "504-508"xsd:string |
| http://purl.uniprot.org/citations/26485346 | http://purl.uniprot.org/core/title | "Are RIG-1 and MDA5 Expressions Associated with Chronic HBV Infection?"xsd:string |
| http://purl.uniprot.org/citations/26485346 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/26485346 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26485346 |
| http://purl.uniprot.org/citations/26485346 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26485346 |
| http://purl.uniprot.org/uniprot/#_A8KA76-mappedCitation-26485346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26485346 |
| http://purl.uniprot.org/uniprot/#_B3KN51-mappedCitation-26485346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26485346 |
| http://purl.uniprot.org/uniprot/#_B4DWT9-mappedCitation-26485346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26485346 |
| http://purl.uniprot.org/uniprot/#_B3KWW1-mappedCitation-26485346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26485346 |
| http://purl.uniprot.org/uniprot/#_Q3B797-mappedCitation-26485346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26485346 |