| http://purl.uniprot.org/citations/26489517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26489517 | http://www.w3.org/2000/01/rdf-schema#comment | "Aquaporin-9 (AQP9), a water/glycerol channel protein, is expressed in several immune cells including neutrophils; however, its role in immune response remains unknown. Here we show the involvement of AQP9 in hapten-induced contact hypersensitivity (CHS), as a murine model of skin allergic contact dermatitis, using AQP9 knockout (AQP9(-/-)) mice. First, the CHS response to hapten dinitrofluorobenzene (DNFB) was impaired in AQP9(-/-) mice compared with wild-type (WT) mice. Adoptive transfer of sensitized AQP9(-/-) draining lymph node (dLN) cells into WT recipients resulted in a reduced CHS response, indicating impaired sensitization in AQP9(-/-) mice. Second, administration of WT neutrophils into AQP9(-/-) mice during sensitization rescued the impaired CHS response. Neutrophil recruitment to dLNs upon hapten application was attenuated by AQP9 deficiency. Coincidentally, AQP9(-/-) neutrophils showed a reduced CC-chemokine receptor 7 (CCR7) ligand-induced migration efficacy, which was attributed to the attenuated recruitment of neutrophils to dLNs. Furthermore, we found that neutrophil deficiency, observed in AQP9(-/-) or neutrophil-depleted mice, decreased IL-17A production by dLN cells, which might be responsible for T cell activation during a subsequent CHS response. Taken together, these findings suggest that AQP9 is required for the development of sensitization during cutaneous acquired immune responses via regulating neutrophil function."xsd:string |
| http://purl.uniprot.org/citations/26489517 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep15319"xsd:string |
| http://purl.uniprot.org/citations/26489517 | http://purl.uniprot.org/core/author | "Honda T."xsd:string |
| http://purl.uniprot.org/citations/26489517 | http://purl.uniprot.org/core/author | "Watanabe S."xsd:string |
| http://purl.uniprot.org/citations/26489517 | http://purl.uniprot.org/core/author | "Nielsen S."xsd:string |
| http://purl.uniprot.org/citations/26489517 | http://purl.uniprot.org/core/author | "Hara-Chikuma M."xsd:string |
| http://purl.uniprot.org/citations/26489517 | http://purl.uniprot.org/core/author | "Moniaga C.S."xsd:string |
| http://purl.uniprot.org/citations/26489517 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26489517 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/26489517 | http://purl.uniprot.org/core/pages | "15319"xsd:string |
| http://purl.uniprot.org/citations/26489517 | http://purl.uniprot.org/core/title | "Aquaporin-9-expressing neutrophils are required for the establishment of contact hypersensitivity."xsd:string |
| http://purl.uniprot.org/citations/26489517 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/26489517 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26489517 |
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