| http://purl.uniprot.org/citations/26490118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26490118 | http://www.w3.org/2000/01/rdf-schema#comment | "Prions are self-propagating, infectious proteins that underlie several neurodegenerative diseases. The molecular basis underlying their sporadic formation is poorly understood. We show that autophagy protects against de novo formation of [PSI(+)], which is the prion form of the yeast Sup35 translation termination factor. Autophagy is a cellular degradation system, and preventing autophagy by mutating its core components elevates the frequency of spontaneous [PSI(+)] formation. Conversely, increasing autophagic flux by treating cells with the polyamine spermidine suppresses prion formation in mutants that normally show a high frequency of de novo prion formation. Autophagy also protects against the de novo formation of another prion, namely the Rnq1/[PIN(+)] prion, which is not related in sequence to the Sup35/[PSI(+)] prion. We show that growth under anaerobic conditions in the absence of molecular oxygen abrogates Sup35 protein damage and suppresses the high frequency of [PSI(+)] formation in an autophagy mutant. Autophagy therefore normally functions to remove oxidatively damaged Sup35, which accumulates in cells grown under aerobic conditions, but in the absence of autophagy, damaged/misfolded Sup35 undergoes structural transitions favoring its conversion to the propagatable [PSI(+)] form."xsd:string |
| http://purl.uniprot.org/citations/26490118 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e15-08-0548"xsd:string |
| http://purl.uniprot.org/citations/26490118 | http://purl.uniprot.org/core/author | "Grant C.M."xsd:string |
| http://purl.uniprot.org/citations/26490118 | http://purl.uniprot.org/core/author | "Speldewinde S.H."xsd:string |
| http://purl.uniprot.org/citations/26490118 | http://purl.uniprot.org/core/author | "Doronina V.A."xsd:string |
| http://purl.uniprot.org/citations/26490118 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26490118 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/26490118 | http://purl.uniprot.org/core/pages | "4541-4551"xsd:string |
| http://purl.uniprot.org/citations/26490118 | http://purl.uniprot.org/core/title | "Autophagy protects against de novo formation of the [PSI+] prion in yeast."xsd:string |
| http://purl.uniprot.org/citations/26490118 | http://purl.uniprot.org/core/volume | "26"xsd:string |
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| http://purl.uniprot.org/uniprot/#_P40458-mappedCitation-26490118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26490118 |
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