| http://purl.uniprot.org/citations/26491021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26491021 | http://www.w3.org/2000/01/rdf-schema#comment | "Eukaryotic structural maintenance of chromosome proteins (SMC) are major components of cohesin and condensins that regulate chromosome structure and dynamics during cell cycle. We here determine the crystal structure of human condensin SMC hinge heterodimer with ~30 residues of coiled coils. The structure, in conjunction with the hydrogen exchange mass spectrometry analyses, revealed the structural basis for the specific heterodimer formation of eukaryotic SMC and that the coiled coils from two different hinges protrude in the same direction, providing a unique binding surface conducive for binding to single-stranded DNA. The characteristic hydrogen exchange profiles of peptides constituted regions especially across the hinge-hinge dimerization interface, further suggesting the structural alterations upon single-stranded DNA binding and the presence of a half-opened state of hinge heterodimer. This structural change potentially relates to the DNA loading mechanism of SMC, in which the hinge domain functions as an entrance gate as previously proposed for cohesin. Our results, however, indicated that this is not the case for condensins based on the fact that the coiled coils are still interacting with each other, even when DNA binding induces structural changes in the hinge region, suggesting the functional differences of SMC hinge domain between condensins and cohesin in DNA recognition."xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m115.670794"xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/author | "Fukui K."xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/author | "Kobayashi Y."xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/author | "Nakamura S."xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/author | "Uchiyama S."xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/author | "Hosokawa Y."xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/author | "Noda M."xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/author | "Kojima Y."xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/author | "Ohkubo T."xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/author | "Kawahara K."xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/author | "Oki H."xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/author | "Miyahara Y."xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/author | "Maruno T."xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/author | "Fukakusa S."xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/author | "Takino R."xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/pages | "29461-29477"xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/title | "Structural Basis for Dimer Formation of Human Condensin Structural Maintenance of Chromosome Proteins and Its Implications for Single-stranded DNA Recognition."xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://purl.uniprot.org/core/volume | "290"xsd:string |
| http://purl.uniprot.org/citations/26491021 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26491021 |
| http://purl.uniprot.org/citations/26491021 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26491021 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DGE5-mappedCitation-26491021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26491021 |