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http://purl.uniprot.org/citations/26496879http://www.w3.org/2000/01/rdf-schema#comment"

Background

Studies report conflicting evidence regarding the existence of a DCIS-associated premalignant pathway in BRCA mutation carriers. We aimed to examine the prevalence, phenotype, and expression of oncodrivers in pure DCIS (pDCIS) and invasive breast cancer with concurrent DCIS (IBC + DCIS) in mutation carriers.

Methods

A cohort of BRCA1 and BRCA2 mutation carriers >18 years old who underwent surgery for breast cancer at an academic hospital (1992-2011) and had pathology available for review were included for study. Invasive breast cancer (IBC) and DCIS were stained for ER, PR, HER1, HER2, and HER3, and C-MET. DCIS prevalence was evaluated. Correlation of IBC and DCIS phenotypes was evaluated in patients with IBC + DCIS. DCIS and IBC expression of tumor markers were examined by BRCA mutation.

Results

We identified 114 breast tumors. Of all BRCA1-associated tumors, 21.1 % were pDCIS and 63.4 % were IBC + DCIS. Of all BRCA2-associated tumors, 23.3 % were pDCIS and 60.5 % were IBC + DCIS. In BRCA1 and BRCA2 mutation carriers with IBC + DCIS, there was a significant correlation in ER, PR, and HER3 expression between the DCIS and IBC components. Most BRCA1-associated DCIS did not express ER, PR or HER2, while most BRCA2-associated DCIS did express ER and PR. BRCA1-as well as BRCA2-associated DCIS had expression of HER3 and C-MET.

Conclusions

The majority of BRCA-associated tumors had DCIS present. Concordance of DCIS and IBC phenotypes was high, arguing for the existence of a DCIS-associated premalignant pathway. Oncodrivers HER3 and C-MET were expressed in the DCIS of mutation carriers, suggesting an opportunity for prevention strategies."xsd:string
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http://purl.uniprot.org/citations/26496879http://purl.uniprot.org/core/author"Lee K."xsd:string
http://purl.uniprot.org/citations/26496879http://purl.uniprot.org/core/author"Nathanson K.L."xsd:string
http://purl.uniprot.org/citations/26496879http://purl.uniprot.org/core/author"Domchek S.M."xsd:string
http://purl.uniprot.org/citations/26496879http://purl.uniprot.org/core/author"Zhang P.J."xsd:string
http://purl.uniprot.org/citations/26496879http://purl.uniprot.org/core/author"Yang R.L."xsd:string
http://purl.uniprot.org/citations/26496879http://purl.uniprot.org/core/author"Mick R."xsd:string
http://purl.uniprot.org/citations/26496879http://purl.uniprot.org/core/author"Czerniecki B.J."xsd:string
http://purl.uniprot.org/citations/26496879http://purl.uniprot.org/core/author"Graves H.L."xsd:string
http://purl.uniprot.org/citations/26496879http://purl.uniprot.org/core/author"Kelz R.R."xsd:string
http://purl.uniprot.org/citations/26496879http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/26496879http://purl.uniprot.org/core/name"J Transl Med"xsd:string
http://purl.uniprot.org/citations/26496879http://purl.uniprot.org/core/pages"335"xsd:string
http://purl.uniprot.org/citations/26496879http://purl.uniprot.org/core/title"DCIS in BRCA1 and BRCA2 mutation carriers: prevalence, phenotype, and expression of oncodrivers C-MET and HER3."xsd:string
http://purl.uniprot.org/citations/26496879http://purl.uniprot.org/core/volume"13"xsd:string
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