| http://purl.uniprot.org/citations/26497687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26497687 | http://www.w3.org/2000/01/rdf-schema#comment | "Several studies have indicated an important role for miR-155 in the pathogenesis of B-cell lymphoma. Highly elevated levels of miR-155 were indeed observed in most B-cell lymphomas with the exception of Burkitt lymphoma (BL). However, the molecular mechanisms that underlie the oncogenic role of miR-155 in B-cell lymphoma are not well understood. To identify the miR-155 targets relevant for B-cell lymphoma, we performed RNA immunoprecipitation of Argonaute 2 in Hodgkin lymphoma (HL) cells upon miR-155 inhibition and in BL cells upon ectopic expression of miR-155. We identified 54 miR-155-specific target genes in BL cells and confirmed miR-155 targeting of DET1, NIAM, TRIM32, HOMEZ, PSIP1 and JARID2. Five of these targets are also regulated by endogenous miR-155 in HL cells. Both overexpression of miR-155 and inhibition of expression of the novel miR-155 target gene NIAM increased proliferation of BL cells. In primary B-cell lymphoma NIAM-positive cases have significant lower levels of miR-155 as compared to NIAM-negative cases, suggesting that NIAM is also regulated by miR-155 in primary B-cell lymphoma. Thus, our data indicate an oncogenic role for miR-155 in B-cell lymphoma which involves targeting the tumor suppressor NIAM."xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.6165"xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://purl.uniprot.org/core/author | "Visser L."xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://purl.uniprot.org/core/author | "de Jong D."xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://purl.uniprot.org/core/author | "Diepstra A."xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://purl.uniprot.org/core/author | "Kluiver J."xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://purl.uniprot.org/core/author | "Koerts J."xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://purl.uniprot.org/core/author | "Rutgers B."xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://purl.uniprot.org/core/author | "Slezak-Prochazka I."xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://purl.uniprot.org/core/author | "van den Berg A."xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://purl.uniprot.org/core/author | "Winkle M."xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://purl.uniprot.org/core/author | "Kroesen B.J."xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://purl.uniprot.org/core/author | "Kortman G."xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://purl.uniprot.org/core/author | "Smigielska-Czepiel K."xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26497687 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://purl.uniprot.org/core/pages | "2391-2400"xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://purl.uniprot.org/core/title | "Inhibition of the miR-155 target NIAM phenocopies the growth promoting effect of miR-155 in B-cell lymphoma."xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/26497687 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26497687 |
| http://purl.uniprot.org/citations/26497687 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26497687 |
| http://purl.uniprot.org/uniprot/#_Q05BL0-mappedCitation-26497687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26497687 |
| http://purl.uniprot.org/uniprot/#_Q3YBR2-mappedCitation-26497687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26497687 |
| http://purl.uniprot.org/uniprot/#_Q6GPH2-mappedCitation-26497687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26497687 |