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http://purl.uniprot.org/citations/26498496http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26498496http://www.w3.org/2000/01/rdf-schema#comment"

Background

Characterising the correlates of HIV persistence improves understanding of disease pathogenesis and guides the design of curative strategies. This study investigated factors associated with integrated HIV-1 DNA load during consistently suppressive first-line antiretroviral therapy (ART).

Method

Total, integrated, and 2-long terminal repeats (LTR) circular HIV-1 DNA, residual plasma HIV-1 RNA, T-cell activation markers, and soluble CD14 (sCD14) were measured in peripheral blood of 50 patients that had received 1-14 years of efavirenz-based or nevirapine-based therapy.

Results

Integrated HIV-1 DNA load (per 10(6) peripheral blood mononuclear cells) was median 1.9 log10 copies (interquartile range 1.7-2.2) and showed a mean difference of 0.2 log10 copies per 10 years of suppressive ART (95% confidence interval - 0.2, 0.6; p = 0.28). It was positively correlated with total HIV-1 DNA load and frequency of CD8(+)HLA-DR/DP/DQ(+) cells, and was also higher in subjects with higher sCD14 levels, but showed no correlation with levels of 2-LTR circular HIV-1 DNA and residual plasma HIV-1 RNA, or the frequency of CD4(+)CD38(+) and CD8(+)CD38(+) cells. Adjusting for pre-ART viral load, duration of suppressive ART, CD4 cell counts, residual plasma HIV-1 RNA levels, and sCD14 levels, integrated HIV-1 DNA load was mean 0.5 log10 copies higher for each 50% higher frequency of CD8(+)HLA-DR/DP/DQ(+) cells (95% confidence interval 0.2, 0.9; p = 0.01).

Conclusions

The observed positive association between integrated HIV-1 DNA load and frequency of CD8(+)DR/DP/DQ(+) cells indicates that a close correlation between HIV persistence and immune activation continues during consistently suppressive therapy. The inducers of the distinct activation profile warrant further investigation."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.org/dc/terms/identifier"doi:10.1016/j.ebiom.2015.07.025"xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"Ruggiero A."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"Waters A."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"Pollakis G."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"Fox J."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"Edwards S."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"Phillips A."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"Ainsworth J."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"Cozzi-Lepri A."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"Vandekerckhove L."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"Geretti A.M."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"Richman D."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"Strain M."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"Beloukas A."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"Vitiello P."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"Mackie N."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"Post F."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"De Spiegelaere W."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/author"Kiselinova M."xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/name"EBioMedicine"xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/pages"1153-1159"xsd:string
http://purl.uniprot.org/citations/26498496http://purl.uniprot.org/core/title"During Stably Suppressive Antiretroviral Therapy Integrated HIV-1 DNA Load in Peripheral Blood is Associated with the Frequency of CD8 Cells Expressing HLA-DR/DP/DQ."xsd:string
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