| http://purl.uniprot.org/citations/26498692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26498692 | http://www.w3.org/2000/01/rdf-schema#comment | "microRNAs have been implicated in hepatocellular carcinoma (HCC) metastasis, which is predominant cause of high mortality in these patients. Although an increasing body of evidence indicates that miR-149 plays an important role in the growth and metastasis of multiple types of cancers, its role in the progression of HCC remains unknown. Here, we demonstrated that miR-149 was significantly down-regulated in HCC, which was correlated with distant metastasis and TNM stage with statistical significance. A survival analysis showed that decreased miR-149 expression was correlated with a poor prognosis of HCC as well. We found that over-expression of miR-149 suppressed migration and invasion of HCC cells in vitro. In addition, we identified PPM1F (protein phosphatase, Mg(2+)/Mn(2+)-dependent, 1F) as a direct target of miR-149 whose expression was negatively correlated with the expression of miR-149 in HCC tissues. The re-expression of PPM1F rescued the miR-149-mediated inhibition of cell migration and invasion. miR-149 regulated formation of stress fibers to inhibit migration, and re-expression of PPM1F reverted the miR-149-mediated loss of stress fibers. Moreover, we demonstrated that over-expression of miR-149 reduced pMLC2, a downstream effector of PPM1F, in MHCC-97H cells. In vivo studies confirm inhibition of HCC metastasis by miR-149. Taken together, our findings indicates that miR-149 is a potential prognostic biomarker of HCC and that the miR-149/PPM1F regulatory axis represents a novel therapeutic target for HCC treatment."xsd:string |
| http://purl.uniprot.org/citations/26498692 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.5676"xsd:string |
| http://purl.uniprot.org/citations/26498692 | http://purl.uniprot.org/core/author | "Dong H."xsd:string |
| http://purl.uniprot.org/citations/26498692 | http://purl.uniprot.org/core/author | "Luo G."xsd:string |
| http://purl.uniprot.org/citations/26498692 | http://purl.uniprot.org/core/author | "Tang B."xsd:string |
| http://purl.uniprot.org/citations/26498692 | http://purl.uniprot.org/core/author | "Wang S.M."xsd:string |
| http://purl.uniprot.org/citations/26498692 | http://purl.uniprot.org/core/author | "Xie R."xsd:string |
| http://purl.uniprot.org/citations/26498692 | http://purl.uniprot.org/core/author | "Yang S.M."xsd:string |
| http://purl.uniprot.org/citations/26498692 | http://purl.uniprot.org/core/author | "Wu Y.Y."xsd:string |
| http://purl.uniprot.org/citations/26498692 | http://purl.uniprot.org/core/author | "Liu X.D."xsd:string |
| http://purl.uniprot.org/citations/26498692 | http://purl.uniprot.org/core/author | "Xiao Y.F."xsd:string |
| http://purl.uniprot.org/citations/26498692 | http://purl.uniprot.org/core/author | "Li B.S."xsd:string |
| http://purl.uniprot.org/citations/26498692 | http://purl.uniprot.org/core/author | "Chao Y.L."xsd:string |
| http://purl.uniprot.org/citations/26498692 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26498692 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/26498692 | http://purl.uniprot.org/core/pages | "37808-37823"xsd:string |
| http://purl.uniprot.org/citations/26498692 | http://purl.uniprot.org/core/title | "miR-149 represses metastasis of hepatocellular carcinoma by targeting actin-regulatory proteins PPM1F."xsd:string |
| http://purl.uniprot.org/citations/26498692 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26498692 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26498692 |
| http://purl.uniprot.org/citations/26498692 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26498692 |
| http://purl.uniprot.org/uniprot/P49593#attribution-73C0BD3290811F1C33CF668BD9620694 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26498692 |
| http://purl.uniprot.org/uniprot/#_A0M8Q2-mappedCitation-26498692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26498692 |
| http://purl.uniprot.org/uniprot/#_A8MX49-mappedCitation-26498692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26498692 |
| http://purl.uniprot.org/uniprot/#_B3KX06-mappedCitation-26498692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26498692 |