| http://purl.uniprot.org/citations/26503810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26503810 | http://www.w3.org/2000/01/rdf-schema#comment | "N-acetyltransferase 2 (NAT2) is responsible for metabolizing xenobiotics; NAT2 polymorphisms lead to three phenotypes: rapid, intermediate and slow acetylators. We aimed to investigate NAT2 diversity in Native Americans. NAT2 exon 2 was sequenced for 286 individuals from 21 populations (Native American and American Mestizos). Excluding the basal/rapid haplotype NAT2*4, the most frequent haplotypes are NAT2*5B (35.95%) in hunter-gatherers and NAT2*7B (20.61%) and NAT2*5B (19.08%) in agriculturalists that were related to the slow phenotype. A new haplotype was identified in two Amerindians. Data from the ~44 kb region surrounding NAT2 in 819 individuals from Africa, East-Asia, Europe and America were used in additional analyses. No significant differences in the acetylator NAT2 haplotype and phenotype distributions were found between Native American populations practicing farming and/or herding and those practicing hunting and gathering, probably because of the absence or weakness of selection pressures and presence of demographic and random processes preventing detection of any selection signal."xsd:string |
| http://purl.uniprot.org/citations/26503810 | http://purl.org/dc/terms/identifier | "doi:10.1038/tpj.2015.72"xsd:string |
| http://purl.uniprot.org/citations/26503810 | http://purl.uniprot.org/core/author | "Bortolini M.C."xsd:string |
| http://purl.uniprot.org/citations/26503810 | http://purl.uniprot.org/core/author | "Salzano F.M."xsd:string |
| http://purl.uniprot.org/citations/26503810 | http://purl.uniprot.org/core/author | "Acuna-Alonzo V."xsd:string |
| http://purl.uniprot.org/citations/26503810 | http://purl.uniprot.org/core/author | "Hunemeier T."xsd:string |
| http://purl.uniprot.org/citations/26503810 | http://purl.uniprot.org/core/author | "Ramallo V."xsd:string |
| http://purl.uniprot.org/citations/26503810 | http://purl.uniprot.org/core/author | "Demarchi D.A."xsd:string |
| http://purl.uniprot.org/citations/26503810 | http://purl.uniprot.org/core/author | "Sandoval J.R."xsd:string |
| http://purl.uniprot.org/citations/26503810 | http://purl.uniprot.org/core/author | "Paixao-Cortes V.R."xsd:string |
| http://purl.uniprot.org/citations/26503810 | http://purl.uniprot.org/core/author | "Bisso-Machado R."xsd:string |
| http://purl.uniprot.org/citations/26503810 | http://purl.uniprot.org/core/author | "Granara A.A."xsd:string |
| http://purl.uniprot.org/citations/26503810 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26503810 | http://purl.uniprot.org/core/name | "Pharmacogenomics J"xsd:string |
| http://purl.uniprot.org/citations/26503810 | http://purl.uniprot.org/core/pages | "559-565"xsd:string |
| http://purl.uniprot.org/citations/26503810 | http://purl.uniprot.org/core/title | "NAT2 gene diversity and its evolutionary trajectory in the Americas."xsd:string |
| http://purl.uniprot.org/citations/26503810 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/26503810 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26503810 |
| http://purl.uniprot.org/citations/26503810 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26503810 |
| http://purl.uniprot.org/uniprot/#_A0A0S2A5S1-mappedCitation-26503810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26503810 |
| http://purl.uniprot.org/uniprot/#_A0A0S2A5X5-mappedCitation-26503810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26503810 |
| http://purl.uniprot.org/uniprot/#_A0A0S2A4Q6-mappedCitation-26503810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26503810 |
| http://purl.uniprot.org/uniprot/#_A0A0S2A5J2-mappedCitation-26503810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26503810 |
| http://purl.uniprot.org/uniprot/#_A4Z6U4-mappedCitation-26503810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26503810 |