Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/26504029http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26504029http://www.w3.org/2000/01/rdf-schema#comment"

Background

Cytokine-mediated immune and inflammatory responses are considered to play an important role in the pathogenesis of prostate cancer. The present study investigated certain interleukin-1β (IL1β) polymorphisms and their association with prostate cancer.

Materials and methods

Genotyping of the IL1B-31(rs 1143627 G>A) and IL1B-511(rs 16944 AResultsThe frequency of the IL1B-31(rs1143627) AG heterozygote genotype was found to be significantly lower in patients compared to controls (odds ratio=0.648, 95% confidence interval=0.463-0.908; p=0.036). The genotypic frequencies of IL1B-511(rs16944) between prostate cancer patients and controls were statistically significantly different (p=0.001). The frequency of AG genotype for IL1B-511(rs16944) was 0.5-fold lower in patients with prostate cancer than in the controls (odds ratio=0.546; 95% confidence interval=0.377-0.791; p=0.001).

Conclusion

Our data show that individuals carrying the IL1B-31(rs1143627) and IL1B-511(rs16944) AG genotypes had a decreased risk for developing prostate cancer. Out of all the possible combinations analyzed, IL1B-31(rs1143627) G with IL1B-511(rs16944) G combination had a protective association with prostate cancer."xsd:string
http://purl.uniprot.org/citations/26504029http://purl.uniprot.org/core/author"Yildirim A."xsd:string
http://purl.uniprot.org/citations/26504029http://purl.uniprot.org/core/author"Yilmaz S.G."xsd:string
http://purl.uniprot.org/citations/26504029http://purl.uniprot.org/core/author"Isbir T."xsd:string
http://purl.uniprot.org/citations/26504029http://purl.uniprot.org/core/author"Dalan A.B."xsd:string
http://purl.uniprot.org/citations/26504029http://purl.uniprot.org/core/author"Altinkilic E.M."xsd:string
http://purl.uniprot.org/citations/26504029http://purl.uniprot.org/core/author"Bastug Y."xsd:string
http://purl.uniprot.org/citations/26504029http://purl.uniprot.org/core/author"Yencilek F."xsd:string
http://purl.uniprot.org/citations/26504029http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/26504029http://purl.uniprot.org/core/name"Anticancer Res"xsd:string
http://purl.uniprot.org/citations/26504029http://purl.uniprot.org/core/pages"6057-6061"xsd:string
http://purl.uniprot.org/citations/26504029http://purl.uniprot.org/core/title"Investigation of Interleukin-1beta Polymorphisms in Prostate Cancer."xsd:string
http://purl.uniprot.org/citations/26504029http://purl.uniprot.org/core/volume"35"xsd:string
http://purl.uniprot.org/citations/26504029http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26504029
http://purl.uniprot.org/citations/26504029http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26504029
http://purl.uniprot.org/uniprot/#_A0A510GAG5-mappedCitation-26504029http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26504029
http://purl.uniprot.org/uniprot/#_A0AA51YZX7-mappedCitation-26504029http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26504029
http://purl.uniprot.org/uniprot/#_B5BUQ8-mappedCitation-26504029http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26504029
http://purl.uniprot.org/uniprot/#_O43645-mappedCitation-26504029http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26504029
http://purl.uniprot.org/uniprot/#_P01584-mappedCitation-26504029http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26504029
http://purl.uniprot.org/uniprot/A0AA51YZX7http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/26504029
http://purl.uniprot.org/uniprot/B5BUQ8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/26504029
http://purl.uniprot.org/uniprot/O43645http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/26504029
http://purl.uniprot.org/uniprot/P01584http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/26504029
▶