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| http://purl.uniprot.org/citations/26504165 | http://www.w3.org/2000/01/rdf-schema#comment | "Stable intronic sequence RNAs (sisRNAs) have been found in Xenopus tropicalis, human cell lines, and Epstein-Barr virus; however, the biological significance of sisRNAs remains poorly understood. We identify sisRNAs in Drosophila melanogaster by deep sequencing, reverse transcription polymerase chain reaction, and Northern blotting. We characterize a sisRNA (sisR-1) from the regena (rga) locus and show that it can be processed from the precursor messenger RNA (pre-mRNA). We also document a cis-natural antisense transcript (ASTR) from the rga locus, which is highly expressed in early embryos. During embryogenesis, ASTR promotes robust rga pre-mRNA expression. Interestingly, sisR-1 represses ASTR, with consequential effects on rga pre-mRNA expression. Our results suggest a model in which sisR-1 modulates its host gene expression by repressing ASTR during embryogenesis. We propose that sisR-1 belongs to a class of sisRNAs with probable regulatory activities in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/26504165 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201507065"xsd:string |
| http://purl.uniprot.org/citations/26504165 | http://purl.uniprot.org/core/author | "Pek J.W."xsd:string |
| http://purl.uniprot.org/citations/26504165 | http://purl.uniprot.org/core/author | "Tay M.L."xsd:string |
| http://purl.uniprot.org/citations/26504165 | http://purl.uniprot.org/core/author | "Osman I."xsd:string |
| http://purl.uniprot.org/citations/26504165 | http://purl.uniprot.org/core/author | "Zheng R.T."xsd:string |
| http://purl.uniprot.org/citations/26504165 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26504165 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/26504165 | http://purl.uniprot.org/core/pages | "243-251"xsd:string |
| http://purl.uniprot.org/citations/26504165 | http://purl.uniprot.org/core/title | "Stable intronic sequence RNAs have possible regulatory roles in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/26504165 | http://purl.uniprot.org/core/volume | "211"xsd:string |
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