| http://purl.uniprot.org/citations/26506419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26506419 | http://www.w3.org/2000/01/rdf-schema#comment | "Although altered metabolic pathway is an important diagnostic maker and therapeutic target in cancer, it is poorly understood in cancer stem cells (CSCs). Here we show that the CD133 (+) hepatocellular CSCs have distinct metabolic properties, characterized by more active glycolysis over oxidative phosphorylation, compared to the CD133 (-) cells. Inhibition of PDK4 and LDHA markedly suppresses CD133 (+) stemness characteristics and overcome resistance to sorafenib (current chemotherapeutic agent for hepatocellular cancer). Addition of glucose or lactate to CD133 (-) cells promotes CSC phenotypes, as evidenced by increased CD133 (+) cell population, elevated stemness gene expression and enhanced spheroid formation. Furthermore, the liver-specific miRNA, miR-122, inhibits CSC phenotypes by regulating glycolysis through targeting PDK4. Our findings suggest that enhanced glycolysis is associated with CD133 (+) stem-like characteristics and that metabolic reprogramming through miR-122 or PDK4 may represent a novel therapeutic approach for the treatment of hepatocellular cancer."xsd:string |
| http://purl.uniprot.org/citations/26506419 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.5812"xsd:string |
| http://purl.uniprot.org/citations/26506419 | http://purl.uniprot.org/core/author | "Han C."xsd:string |
| http://purl.uniprot.org/citations/26506419 | http://purl.uniprot.org/core/author | "Lim K."xsd:string |
| http://purl.uniprot.org/citations/26506419 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/26506419 | http://purl.uniprot.org/core/author | "Wu T."xsd:string |
| http://purl.uniprot.org/citations/26506419 | http://purl.uniprot.org/core/author | "Song K."xsd:string |
| http://purl.uniprot.org/citations/26506419 | http://purl.uniprot.org/core/author | "Kwon H."xsd:string |
| http://purl.uniprot.org/citations/26506419 | http://purl.uniprot.org/core/author | "Dash S."xsd:string |
| http://purl.uniprot.org/citations/26506419 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26506419 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/26506419 | http://purl.uniprot.org/core/pages | "40822-40835"xsd:string |
| http://purl.uniprot.org/citations/26506419 | http://purl.uniprot.org/core/title | "Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122."xsd:string |
| http://purl.uniprot.org/citations/26506419 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26506419 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26506419 |
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