| http://purl.uniprot.org/citations/26508642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26508642 | http://www.w3.org/2000/01/rdf-schema#comment | "Thyroid hormone binds to nuclear receptors and regulates gene transcription. Here we report that in mice, at around the first day of life, there is a transient surge in hepatocyte type 2 deiodinase (D2) that activates the prohormone thyroxine to the active hormone triiodothyronine, modifying the expression of ∼165 genes involved in broad aspects of hepatocyte function, including lipid metabolism. Hepatocyte-specific D2 inactivation (ALB-D2KO) is followed by a delay in neonatal expression of key lipid-related genes and a persistent reduction in peroxisome proliferator-activated receptor-γ expression. Notably, the absence of a neonatal D2 peak significantly modifies the baseline and long-term hepatic transcriptional response to a high-fat diet (HFD). Overall, changes in the expression of approximately 400 genes represent the HFD response in control animals toward the synthesis of fatty acids and triglycerides, whereas in ALB-D2KO animals, the response is limited to a very different set of only approximately 200 genes associated with reverse cholesterol transport and lipase activity. A whole genome methylation profile coupled to multiple analytical platforms indicate that 10-20% of these differences can be related to the presence of differentially methylated local regions mapped to sites of active/suppressed chromatin, thus qualifying as epigenetic modifications occurring as a result of neonatal D2 inactivation. The resulting phenotype of the adult ALB-D2KO mouse is dramatic, with greatly reduced susceptibility to diet-induced steatosis, hypertriglyceridemia, and obesity."xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1508943112"xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/author | "Xing X."xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/author | "Fekete C."xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/author | "Gereben B."xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/author | "Ribeiro M.O."xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/author | "Bianco A.C."xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/author | "Fernandes G.W."xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/author | "Fonseca T.L."xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/author | "Mohacsik P."xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/author | "Bocco B.M."xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/author | "McAninch E.A."xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/author | "Abdalla S.M."xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/pages | "14018-14023"xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/title | "Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity."xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/26508642 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26508642 |
| http://purl.uniprot.org/citations/26508642 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26508642 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQK3-mappedCitation-26508642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26508642 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SV67-mappedCitation-26508642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26508642 |