| http://purl.uniprot.org/citations/26508789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26508789 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila Toll pathway plays important roles in innate immune responses against Gram-positive bacteria and fungi. To identify previously uncharacterized components of this pathway, we performed comparative, ex vivo, genome-wide RNA interference screening. In four screens, we overexpressed the Toll adaptor protein dMyd88, the downstream kinase Pelle, or the nuclear factor κB (NF-κB) homolog Dif, or we knocked down Cactus, the Drosophila homolog of mammalian inhibitor of NF-κB. On the basis of these screens, we identified the E3 ubiquitin ligase Sherpa as being necessary for the activation of Toll signaling. A loss-of-function sherpa mutant fly exhibited compromised production of antimicrobial peptides and enhanced susceptibility to infection by Gram-positive bacteria. In cultured cells, Sherpa mediated ubiquitylation of dMyd88 and Sherpa itself, and Sherpa and Drosophila SUMO (small ubiquitin-like modifier) were required for the proper membrane localization of an adaptor complex containing dMyd88. These findings highlight a role for Sherpa in Drosophila host defense and suggest the SUMOylation-mediated regulation of dMyd88 functions in Toll innate immune signaling."xsd:string |
| http://purl.uniprot.org/citations/26508789 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.2005971"xsd:string |
| http://purl.uniprot.org/citations/26508789 | http://purl.uniprot.org/core/author | "Kurata S."xsd:string |
| http://purl.uniprot.org/citations/26508789 | http://purl.uniprot.org/core/author | "Suda Y."xsd:string |
| http://purl.uniprot.org/citations/26508789 | http://purl.uniprot.org/core/author | "Kanoh H."xsd:string |
| http://purl.uniprot.org/citations/26508789 | http://purl.uniprot.org/core/author | "Kuraishi T."xsd:string |
| http://purl.uniprot.org/citations/26508789 | http://purl.uniprot.org/core/author | "Shishido F."xsd:string |
| http://purl.uniprot.org/citations/26508789 | http://purl.uniprot.org/core/author | "Momiuchi Y."xsd:string |
| http://purl.uniprot.org/citations/26508789 | http://purl.uniprot.org/core/author | "Tong L.L."xsd:string |
| http://purl.uniprot.org/citations/26508789 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26508789 | http://purl.uniprot.org/core/name | "Sci Signal"xsd:string |
| http://purl.uniprot.org/citations/26508789 | http://purl.uniprot.org/core/pages | "ra107"xsd:string |
| http://purl.uniprot.org/citations/26508789 | http://purl.uniprot.org/core/title | "Genome-wide RNAi screening implicates the E3 ubiquitin ligase Sherpa in mediating innate immune signaling by Toll in Drosophila adults."xsd:string |
| http://purl.uniprot.org/citations/26508789 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/26508789 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26508789 |
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