| http://purl.uniprot.org/citations/26510792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26510792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26510792 | http://www.w3.org/2000/01/rdf-schema#comment | "Meiosis is a tightly regulated process requiring coordination of diverse events. A conserved ERK/MAPK-signaling cascade plays an essential role in the regulation of meiotic progression. The Thousand And One kinase (TAO) kinase is a MAPK kinase kinase, the meiotic role of which is unknown. We have analyzed the meiotic functions of KIN-18, the homolog of mammalian TAO kinases, in Caenorhabditis elegans. We found that KIN-18 is essential for normal meiotic progression; mutants exhibit accelerated meiotic recombination as detected both by analysis of recombination intermediates and by crossover outcome. In addition, ectopic germ-cell differentiation and enhanced levels of apoptosis were observed in kin-18 mutants. These defects correlate with ectopic activation of MPK-1 that includes premature, missing, and reoccurring MPK-1 activation. Late progression defects in kin-18 mutants are suppressed by inhibiting an upstream activator of MPK-1 signaling, KSR-2. However, the acceleration of recombination events observed in kin-18 mutants is largely MPK-1-independent. Our data suggest that KIN-18 coordinates meiotic progression by modulating the timing of MPK-1 activation and the progression of recombination events. The regulation of the timing of MPK-1 activation ensures the proper timing of apoptosis and is required for the formation of functional oocytes. Meiosis is a conserved process; thus, revealing that KIN-18 is a novel regulator of meiotic progression in C. elegans would help to elucidate TAO kinase's role in germline development in higher eukaryotes."xsd:string |
| http://purl.uniprot.org/citations/26510792 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.115.177295"xsd:string |
| http://purl.uniprot.org/citations/26510792 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.115.177295"xsd:string |
| http://purl.uniprot.org/citations/26510792 | http://purl.uniprot.org/core/author | "Yin Y."xsd:string |
| http://purl.uniprot.org/citations/26510792 | http://purl.uniprot.org/core/author | "Yin Y."xsd:string |
| http://purl.uniprot.org/citations/26510792 | http://purl.uniprot.org/core/author | "Smolikove S."xsd:string |
| http://purl.uniprot.org/citations/26510792 | http://purl.uniprot.org/core/author | "Smolikove S."xsd:string |
| http://purl.uniprot.org/citations/26510792 | http://purl.uniprot.org/core/author | "Donlevy S."xsd:string |
| http://purl.uniprot.org/citations/26510792 | http://purl.uniprot.org/core/author | "Donlevy S."xsd:string |
| http://purl.uniprot.org/citations/26510792 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26510792 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26510792 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/26510792 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/26510792 | http://purl.uniprot.org/core/pages | "45-59"xsd:string |
| http://purl.uniprot.org/citations/26510792 | http://purl.uniprot.org/core/pages | "45-59"xsd:string |
| http://purl.uniprot.org/citations/26510792 | http://purl.uniprot.org/core/title | "Coordination of Recombination with Meiotic Progression in the Caenorhabditis elegans Germline by KIN-18, a TAO Kinase That Regulates the Timing of MPK-1 Signaling."xsd:string |
| http://purl.uniprot.org/citations/26510792 | http://purl.uniprot.org/core/title | "Coordination of Recombination with Meiotic Progression in the Caenorhabditis elegans Germline by KIN-18, a TAO Kinase That Regulates the Timing of MPK-1 Signaling."xsd:string |
| http://purl.uniprot.org/citations/26510792 | http://purl.uniprot.org/core/volume | "202"xsd:string |
| http://purl.uniprot.org/citations/26510792 | http://purl.uniprot.org/core/volume | "202"xsd:string |
| http://purl.uniprot.org/citations/26510792 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26510792 |
| http://purl.uniprot.org/citations/26510792 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26510792 |
| http://purl.uniprot.org/citations/26510792 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26510792 |
| http://purl.uniprot.org/citations/26510792 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26510792 |