| http://purl.uniprot.org/citations/26511037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26511037 | http://www.w3.org/2000/01/rdf-schema#comment | "CCAAT/enhancer-binding protein α (C/ebpα) is a transcription factor that plays important roles in the regulation of hepatogenesis, adipogenesis and hematopoiesis. Disruption of the C/EBPα gene in mice leads to disturbed liver architecture and neonatal death due to hypoglycemia. However, the precise stages of liver development affected by C/ebpα loss are poorly studied. Using the zebrafish embryo as a model organism, we show that inactivation of the cebpa gene by TALENs results in a small liver phenotype. Further studies reveal that C/ebpα is distinctively required for hepatic outgrowth but not for hepatoblast specification. Lack of C/ebpα leads to enhanced hepatic cell proliferation and subsequent increased cell apoptosis. Additional loss of p53 can largely rescue the hepatic defect in cebpa mutants, suggesting that C/ebpα plays a role in liver growth regulation via the p53 pathway. Thus, our findings for the first time demonstrate a stage-specific role for C/ebpα during liver organogenesis."xsd:string |
| http://purl.uniprot.org/citations/26511037 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep15838"xsd:string |
| http://purl.uniprot.org/citations/26511037 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/26511037 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/26511037 | http://purl.uniprot.org/core/author | "Gao C."xsd:string |
| http://purl.uniprot.org/citations/26511037 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/26511037 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/26511037 | http://purl.uniprot.org/core/author | "Yang R."xsd:string |
| http://purl.uniprot.org/citations/26511037 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/26511037 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/26511037 | http://purl.uniprot.org/core/author | "Yuan H."xsd:string |
| http://purl.uniprot.org/citations/26511037 | http://purl.uniprot.org/core/author | "Wen B."xsd:string |
| http://purl.uniprot.org/citations/26511037 | http://purl.uniprot.org/core/author | "de The H."xsd:string |
| http://purl.uniprot.org/citations/26511037 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26511037 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/26511037 | http://purl.uniprot.org/core/pages | "15838"xsd:string |
| http://purl.uniprot.org/citations/26511037 | http://purl.uniprot.org/core/title | "CCAAT/enhancer-binding protein alpha is required for hepatic outgrowth via the p53 pathway in zebrafish."xsd:string |
| http://purl.uniprot.org/citations/26511037 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/26511037 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26511037 |
| http://purl.uniprot.org/citations/26511037 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26511037 |
| http://purl.uniprot.org/uniprot/Q8UVZ1#attribution-97A9C66F65DAD0CF58627464788F0EA5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26511037 |
| http://purl.uniprot.org/uniprot/#_A0A0B4VFS7-mappedCitation-26511037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26511037 |
| http://purl.uniprot.org/uniprot/#_B0R0M3-mappedCitation-26511037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26511037 |
| http://purl.uniprot.org/uniprot/#_A0A8M2BCD8-mappedCitation-26511037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26511037 |