| http://purl.uniprot.org/citations/26514775 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26514775 | http://www.w3.org/2000/01/rdf-schema#comment | "We tested whether the T helper (Th) type 2 (Th2) cell agonist and allergenic ligand IL-33 was associated with eosinophilic esophagitis (EoE) development in a pediatric cohort and whether IL-33 protein could induce disease symptoms in mice. Biopsies from EoE patients or controls were used to measure IL-33 mRNA and protein expression. Increased expression of IL-33 mRNA was found in the esophageal mucosa in EoE. IL-33 protein was detected in cells negative for CD45, mast cells, and epithelial cell markers near blood vessels. Circulating levels of IL-33 were not increased. The time course for IL-33 gene expression was quantified in an established Aspergillus fumigatus allergen mouse model of EoE. Because IL-33 induction was transient in this model and chronicity of IL-33 expression has been demonstrated in humans, naive mice were treated with recombinant IL-33 for 1 wk and esophageal pathology was evaluated. IL-33 application produced changes consistent with phenotypically early EoE, including transmural eosinophilia, mucosal hyperproliferation, and upregulation of eosinophilic genes and chemokines. Th2 cytokines, including IL-13, along with innate lymphoid cell group 2, Th1/17, and M2 macrophage marker genes, were increased after IL-33 application. IL-33-induced eosinophilia was ablated in IL-13 null mice. In addition, IL-33 induced a profound inhibition of the regulatory T cell gene signature. We conclude that IL-33 gene expression is associated with pediatric EoE development and that application of recombinant protein in mice phenocopies the early clinical phase of the human disease in an IL-13-dependent manner. IL-33 inhibition of esophageal regulatory T cell function may induce loss of antigenic tolerance, thereby providing a mechanistic rationale for EoE development."xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpgi.00290.2015"xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/author | "O'Connor L."xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/author | "Giraud A.S."xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/author | "Scurr M."xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/author | "Allen K.J."xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/author | "Menheniott T.R."xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/author | "Judd L.M."xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/author | "Pavlic D."xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/author | "Mattes J."xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/author | "Collison A.M."xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/author | "Al Gazali K."xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/author | "Buzzelli J."xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/author | "Hamilton O."xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/author | "Heine R.G."xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/author | "O'Brien-Simpson N."xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/name | "Am J Physiol Gastrointest Liver Physiol"xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/pages | "G13-25"xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/title | "Elevated IL-33 expression is associated with pediatric eosinophilic esophagitis, and exogenous IL-33 promotes eosinophilic esophagitis development in mice."xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://purl.uniprot.org/core/volume | "310"xsd:string |
| http://purl.uniprot.org/citations/26514775 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26514775 |
| http://purl.uniprot.org/citations/26514775 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26514775 |
| http://purl.uniprot.org/uniprot/#_A0A1I9RI50-mappedCitation-26514775 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26514775 |