| http://purl.uniprot.org/citations/26514923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26514923 | http://www.w3.org/2000/01/rdf-schema#comment | "Cadmium (Cd), a widespread cumulative pollutant, is a known human carcinogen, associated with inflammation and tumors. Matrix metalloproteinase-9 (MMP-9) plays a pivotal role in tumor metastasis; however, the mechanisms underlying the MMP-9 expression induced by Cd remain obscure in human endothelial cells. Here, Cd elevated MMP-9 expression in dose- and time-dependent manners in human endothelial cells. Cd increased ROS production and the ROS-producing NADPH oxidase. Cd translocates p47(phox), a key subunit of NADPH oxidase, to the cell membrane. Cd also activated the phosphorylation of EGFR, Akt, Erk1/2, and JNK1/2 in addition to promoting NF-кB and AP-1 binding activities. Specific inhibitor and mutagenesis studies showed that EGFR, Akt, Erk1/2, JNK1/2 and transcription factors NF-κB and AP-1 were related to Cd-induced MMP-9 expression in endothelial cells. Akt, Erk1/2, and JNK1/2 functioned as upstream signals in the activation of NF-κB and AP-1, respectively. In addition, N-acetyl-l-cystein (NAC), diphenyleneiodonium chloride (DPI) and apocynin (APO) inhibited the Cd-induced activation of EGFR, Akt, Erk1/2, JNK1/2, and p38 MAPK, indicating that ROS production by NADPH oxidase is the furthest upstream signal in MMP-9 expression. At present, it states that Cd displayed marked invasiveness in ECV304 cells, which was partially abrogated by MMP-9 neutralizing antibodies. These results demonstrated that Cd induces MMP-9 expression via ROS-dependent EGFR->Erk1/2, JNK1/2->AP-1 and EGFR->Akt->NF-κB signaling pathways and, in turn, stimulates invasiveness in human endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/26514923 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.tox.2015.10.008"xsd:string |
| http://purl.uniprot.org/citations/26514923 | http://purl.uniprot.org/core/author | "Kim K.K."xsd:string |
| http://purl.uniprot.org/citations/26514923 | http://purl.uniprot.org/core/author | "Xia Y."xsd:string |
| http://purl.uniprot.org/citations/26514923 | http://purl.uniprot.org/core/author | "Yoon H.J."xsd:string |
| http://purl.uniprot.org/citations/26514923 | http://purl.uniprot.org/core/author | "Kim N.H."xsd:string |
| http://purl.uniprot.org/citations/26514923 | http://purl.uniprot.org/core/author | "Lian S."xsd:string |
| http://purl.uniprot.org/citations/26514923 | http://purl.uniprot.org/core/author | "Jung Y.D."xsd:string |
| http://purl.uniprot.org/citations/26514923 | http://purl.uniprot.org/core/author | "Ung T.T."xsd:string |
| http://purl.uniprot.org/citations/26514923 | http://purl.uniprot.org/core/author | "Khoi P.N."xsd:string |
| http://purl.uniprot.org/citations/26514923 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26514923 | http://purl.uniprot.org/core/name | "Toxicology"xsd:string |
| http://purl.uniprot.org/citations/26514923 | http://purl.uniprot.org/core/pages | "104-116"xsd:string |
| http://purl.uniprot.org/citations/26514923 | http://purl.uniprot.org/core/title | "Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/26514923 | http://purl.uniprot.org/core/volume | "338"xsd:string |
| http://purl.uniprot.org/citations/26514923 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26514923 |
| http://purl.uniprot.org/citations/26514923 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26514923 |
| http://purl.uniprot.org/uniprot/P31749#attribution-02C137DA78C12E370262D2F390E7AA98 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26514923 |
| http://purl.uniprot.org/uniprot/P00533#attribution-02C137DA78C12E370262D2F390E7AA98 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26514923 |
| http://purl.uniprot.org/uniprot/P01100#attribution-02C137DA78C12E370262D2F390E7AA98 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26514923 |
| http://purl.uniprot.org/uniprot/P05412#attribution-02C137DA78C12E370262D2F390E7AA98 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26514923 |
| http://purl.uniprot.org/uniprot/O15111#attribution-02C137DA78C12E370262D2F390E7AA98 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26514923 |
| http://purl.uniprot.org/uniprot/P45984#attribution-02C137DA78C12E370262D2F390E7AA98 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26514923 |
| http://purl.uniprot.org/uniprot/P45983#attribution-02C137DA78C12E370262D2F390E7AA98 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26514923 |