| http://purl.uniprot.org/citations/26515594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26515594 | http://www.w3.org/2000/01/rdf-schema#comment | "In metastatic breast cancers, the acquisition of metastatic ability, which leads to clinically incurable disease and poor survival, has been associated with acquisition of epithelial-mesenchymal transition (EMT) program and self-renewing trait (CSCs) via activation of PI3K/AKT and IL6/JAK2/STAT3 signaling pathways. We found that TrkB is a key regulator of PI3K/AKT and JAK/STAT signal pathway-mediated tumor metastasis and EMT program. Here, we demonstrated that TrkB activates AKT by directly binding to c-Src, leading to increased proliferation. Also, TrkB increases Twist-1 and Twist-2 expression through activation of JAK2/STAT3 by inducing c-Src-JAK2 complex formation. Furthermore, TrkB in the absence of c-Src binds directly to JAK2 and inhibits SOCS3-mediated JAK2 degradation, resulting in increased total JAK2 and STAT3 levels, which subsequently leads to JAK2/STAT3 activation and Twist-1 upregulation. Additionally, activation of the JAK2/STAT3 pathway via induction of IL-6 secretion by TrkB enables induction of activation of the EMT program via induction of STAT3 nuclear translocation. These observations suggest that TrkB is a promising target for future intervention strategies to prevent tumor metastasis, EMT program and self-renewing trait in breast cancer."xsd:string |
| http://purl.uniprot.org/citations/26515594 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.5522"xsd:string |
| http://purl.uniprot.org/citations/26515594 | http://purl.uniprot.org/core/author | "Jin W."xsd:string |
| http://purl.uniprot.org/citations/26515594 | http://purl.uniprot.org/core/author | "Kim S.J."xsd:string |
| http://purl.uniprot.org/citations/26515594 | http://purl.uniprot.org/core/author | "Jeong J."xsd:string |
| http://purl.uniprot.org/citations/26515594 | http://purl.uniprot.org/core/author | "Lee W.S."xsd:string |
| http://purl.uniprot.org/citations/26515594 | http://purl.uniprot.org/core/author | "Kim M.S."xsd:string |
| http://purl.uniprot.org/citations/26515594 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26515594 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/26515594 | http://purl.uniprot.org/core/pages | "40158-40171"xsd:string |
| http://purl.uniprot.org/citations/26515594 | http://purl.uniprot.org/core/title | "Induction of metastatic potential by TrkB via activation of IL6/JAK2/STAT3 and PI3K/AKT signaling in breast cancer."xsd:string |
| http://purl.uniprot.org/citations/26515594 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26515594 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26515594 |
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