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Background

Deregulation of secreted frizzled-related protein 2 (sFRP2) has been found in many types of cancer. However, the pattern of sFRP2 expression in acute myeloid leukemia (AML) is still unclear.

Methods

This study aimed to validate the prognostic significance of sFRP2 expression in 54 older patients with cytogenetic normal acute myeloid leukemia (CN-AML) using real-time quantitative polymerase chain reaction.

Results

sFRP2 expression was decreased markedly in patients compared with controls (P < 0.001). No correlation was found between sFRP2 gene expression and WBCs, hemoglobin, platelets, FAB type, NMP1 and FLT3/ITD mutations at diagnosis. All patients were treated with standard induction chemotherapy. Patients with high sFRP2 expression had higher incidence of complete remission rate (P = 0.04) and better overall survival (P = 0.026). Multivariate analysis revealed that high sFRP2 expression was a prognostic factor for older patients with CN-AML.

Conclusions

This study demonstrated that sFRP2 gene expression at diagnosis had an impact on outcome of elderly CN-AML patients."xsd:string
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http://purl.uniprot.org/citations/26517501http://purl.uniprot.org/core/author"Aly R.M."xsd:string
http://purl.uniprot.org/citations/26517501http://purl.uniprot.org/core/author"Abdsalam E.M."xsd:string
http://purl.uniprot.org/citations/26517501http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/26517501http://purl.uniprot.org/core/name"Am J Med Sci"xsd:string
http://purl.uniprot.org/citations/26517501http://purl.uniprot.org/core/pages"369-373"xsd:string
http://purl.uniprot.org/citations/26517501http://purl.uniprot.org/core/title"Prognostic Significance of Secreted Frizzled-Related Protein 2 Expression in Cytogenetically Normal Primary Acute Myeloid Leukemia."xsd:string
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