| http://purl.uniprot.org/citations/26519536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26519536 | http://www.w3.org/2000/01/rdf-schema#comment | "Upon virus infection, retinoic acid-inducible gene I-like receptors in host cells recognize viral RNA and activate type I IFN expression. Previously, we identified WD repeat domain (WDR) 5 as one positive regulator for pathway activation. In this study, we report that WDR82, a homolog protein of WDR5, acts opposite to WDR5 and inhibits the activation of the retinoic acid-inducible gene I signaling pathway. WDR82 overexpression inhibits virus-triggered pathway activation, whereas its knockdown enhances induced IFN-β expression. WDR82 is localized on the mitochondria, and its first N-terminal WD40 domain is critical for localization. WDR82 interacts with TNFR-associated factor (TRAF) 3, and its overexpression promotes K48-linked, but not K63-linked, polyubiquitination on TRAF3. Furthermore, WDR82 knockdown inhibits viral replication in the cell, whereas its overexpression has the opposite effect. Interestingly, WDR82 regulates Sendai virus-induced IFNB1 expression in a cell type-specific manner. Taken together, our findings demonstrate that WDR82 is a negative regulator of virus-triggered type I IFNs pathway through mediating TRAF3 polyubiquitination status and stability on mitochondria."xsd:string |
| http://purl.uniprot.org/citations/26519536 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1500339"xsd:string |
| http://purl.uniprot.org/citations/26519536 | http://purl.uniprot.org/core/author | "Wu M."xsd:string |
| http://purl.uniprot.org/citations/26519536 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/26519536 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/26519536 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/26519536 | http://purl.uniprot.org/core/author | "Zhu K."xsd:string |
| http://purl.uniprot.org/citations/26519536 | http://purl.uniprot.org/core/author | "Yao J."xsd:string |
| http://purl.uniprot.org/citations/26519536 | http://purl.uniprot.org/core/author | "Li L.Y."xsd:string |
| http://purl.uniprot.org/citations/26519536 | http://purl.uniprot.org/core/author | "Ju L.G."xsd:string |
| http://purl.uniprot.org/citations/26519536 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26519536 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/26519536 | http://purl.uniprot.org/core/pages | "5358-5366"xsd:string |
| http://purl.uniprot.org/citations/26519536 | http://purl.uniprot.org/core/title | "WDR82 Negatively Regulates Cellular Antiviral Response by Mediating TRAF3 Polyubiquitination in Multiple Cell Lines."xsd:string |
| http://purl.uniprot.org/citations/26519536 | http://purl.uniprot.org/core/volume | "195"xsd:string |
| http://purl.uniprot.org/citations/26519536 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26519536 |
| http://purl.uniprot.org/citations/26519536 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26519536 |
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