| http://purl.uniprot.org/citations/26522720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26522720 | http://www.w3.org/2000/01/rdf-schema#comment | "The REL gene, encoding the NF-κB subunit c-Rel, is frequently amplified in B-cell lymphoma and functions as a tumour-promoting transcription factor. Here we report the surprising result that c-rel-/-mice display significantly earlier lymphomagenesis in the c-Myc driven, Eμ-Myc model of B-cell lymphoma. c-Rel loss also led to earlier onset of disease in a separate TCL1-Tg-driven lymphoma model. Tumour reimplantation experiments indicated that this is an effect intrinsic to the Eμ-Myc lymphoma cells but, counterintuitively, c-rel-/-Eμ-Myc lymphoma cells were more sensitive to apoptotic stimuli. To learn more about why loss of c-Rel led to earlier onset of disease, microarray gene expression analysis was performed on B cells from 4-week-old, wild-type and c-rel-/-Eμ-Myc mice. Extensive changes in gene expression were not seen at this age, but among those transcripts significantly downregulated by the loss of c-Rel was the B-cell tumour suppressor BTB and CNC homology 2 (Bach2). Quantitative PCR and western blot analysis confirmed loss of Bach2 in c-Rel mutant Eμ-Myc tumours at both 4 weeks and the terminal stages of disease. Moreover, Bach2 expression was also downregulated in c-rel-/-TCL1-Tg mice and RelA Thr505Ala mutant Eμ-Myc mice. Analysis of wild-type Eμ-Myc mice demonstrated that the population expressing low levels of Bach2 exhibited the earlier onset of lymphoma seen in c-rel-/-mice. Confirming the relevance of these findings to human disease, analysis of chromatin immunoprecipitation sequencing data revealed that Bach2 is a c-Rel and NF-κB target gene in transformed human B cells, whereas treatment of Burkitt's lymphoma cells with inhibitors of the NF-κB/IκB kinase pathway or deletion of c-Rel or RelA resulted in loss of Bach2 expression. These data reveal a surprising tumour suppressor role for c-Rel in lymphoma development explained by regulation of Bach2 expression, underlining the context-dependent complexity of NF-κB signalling in cancer."xsd:string |
| http://purl.uniprot.org/citations/26522720 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2015.399"xsd:string |
| http://purl.uniprot.org/citations/26522720 | http://purl.uniprot.org/core/author | "Gewurz B.E."xsd:string |
| http://purl.uniprot.org/citations/26522720 | http://purl.uniprot.org/core/author | "Zhao B."xsd:string |
| http://purl.uniprot.org/citations/26522720 | http://purl.uniprot.org/core/author | "Perkins N.D."xsd:string |
| http://purl.uniprot.org/citations/26522720 | http://purl.uniprot.org/core/author | "Bacon C.M."xsd:string |
| http://purl.uniprot.org/citations/26522720 | http://purl.uniprot.org/core/author | "Thomas H.D."xsd:string |
| http://purl.uniprot.org/citations/26522720 | http://purl.uniprot.org/core/author | "Campbell K.J."xsd:string |
| http://purl.uniprot.org/citations/26522720 | http://purl.uniprot.org/core/author | "Cockell S.J."xsd:string |
| http://purl.uniprot.org/citations/26522720 | http://purl.uniprot.org/core/author | "Sellier H."xsd:string |
| http://purl.uniprot.org/citations/26522720 | http://purl.uniprot.org/core/author | "Hunter J.E."xsd:string |
| http://purl.uniprot.org/citations/26522720 | http://purl.uniprot.org/core/author | "Butterworth J.A."xsd:string |
| http://purl.uniprot.org/citations/26522720 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26522720 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/26522720 | http://purl.uniprot.org/core/pages | "3476-3484"xsd:string |
| http://purl.uniprot.org/citations/26522720 | http://purl.uniprot.org/core/title | "The NF-kappaB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma."xsd:string |
| http://purl.uniprot.org/citations/26522720 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/26522720 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26522720 |
| http://purl.uniprot.org/citations/26522720 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26522720 |
| http://purl.uniprot.org/uniprot/#_P15307-mappedCitation-26522720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26522720 |
| http://purl.uniprot.org/uniprot/#_A4QPD3-mappedCitation-26522720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26522720 |
| http://purl.uniprot.org/uniprot/#_Q4KL56-mappedCitation-26522720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26522720 |
| http://purl.uniprot.org/uniprot/#_P97303-mappedCitation-26522720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26522720 |
| http://purl.uniprot.org/uniprot/#_Q3TSF4-mappedCitation-26522720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26522720 |