| http://purl.uniprot.org/citations/26522721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26522721 | http://www.w3.org/2000/01/rdf-schema#comment | "ZFP521 was previously identified as a putative gene involved in induction of B-cell lymphomagenesis. However, the contribution of ZFP521 to lymphomagenesis has not been confirmed. In this study, we sought to elucidate the role of ZFP521 in B-cell lymphomagenesis. To this end, we used a retroviral insertion method to show that ZFP521 was a target of mutagenesis in pre-B-lymphoblastic lymphoma cells. The pre-B-cell receptor (pre-BCR) signaling molecules BLNK, BTK and BANK1 were positively regulated by the ZFP521 gene, leading to enhancement of the pre-BCR signaling pathway. In addition, c-myc and c-jun were upregulated following activation of ZFP521. Stimulation of pre-BCR signaling using anti-Vpreb antibodies caused aberrant upregulation of c-myc and c-jun and of Ccnd3, which encodes cyclin D3, thereby inducing the growth of pre-B cells. Stimulation with Vpreb affected the growth of pre-B cells, and addition of interleukin (IL)-7 receptor exerted competitive effects on pre-B-cell growth. Knockdown of BTK and BANK1, targets of ZFP521, suppressed the effects of Vpreb stimulation on cell growth. Furthermore, in human lymphoblastic lymphoma, analogous to pre-B-cell lymphoma in mice, the expression of ZNF521, the homolog of ZFP521 in humans, was upregulated. In conclusion, our data showed that the ZFP521 gene comprehensively induced pre-B-cell lymphomagenesis by modulating the pre-B-cell receptor signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/26522721 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2015.385"xsd:string |
| http://purl.uniprot.org/citations/26522721 | http://purl.uniprot.org/core/author | "Imai Y."xsd:string |
| http://purl.uniprot.org/citations/26522721 | http://purl.uniprot.org/core/author | "Nakamura T."xsd:string |
| http://purl.uniprot.org/citations/26522721 | http://purl.uniprot.org/core/author | "Hiratsuka T."xsd:string |
| http://purl.uniprot.org/citations/26522721 | http://purl.uniprot.org/core/author | "Ozeki M."xsd:string |
| http://purl.uniprot.org/citations/26522721 | http://purl.uniprot.org/core/author | "Takei Y."xsd:string |
| http://purl.uniprot.org/citations/26522721 | http://purl.uniprot.org/core/author | "Haga H."xsd:string |
| http://purl.uniprot.org/citations/26522721 | http://purl.uniprot.org/core/author | "Tamaki K."xsd:string |
| http://purl.uniprot.org/citations/26522721 | http://purl.uniprot.org/core/author | "Tsuruyama T."xsd:string |
| http://purl.uniprot.org/citations/26522721 | http://purl.uniprot.org/core/author | "Ohmori R."xsd:string |
| http://purl.uniprot.org/citations/26522721 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26522721 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/26522721 | http://purl.uniprot.org/core/pages | "3227-3238"xsd:string |
| http://purl.uniprot.org/citations/26522721 | http://purl.uniprot.org/core/title | "ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/26522721 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/26522721 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26522721 |
| http://purl.uniprot.org/citations/26522721 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26522721 |
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| http://purl.uniprot.org/uniprot/#_B0F3S4-mappedCitation-26522721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26522721 |